Diagnostic accuracy of (18)F-FDG-PET/CT in early and late stages of high-risk cutaneous malignant melanoma

Journal of the European Academy of Dermatology and Venereology : JEADV
E GellénG Emri

Abstract

The precise role of total body (18) F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) in the clinical management of patients with cutaneous malignant melanoma (CMM) is not well established. The purpose of this study was to investigate the diagnostic accuracy of PET/CT in early- and late-stage patients with high-risk CMM. We retrospectively analysed various imaging, histopathological and clinical data from 97 patients also examined by PET/CT during a 5-year period (2007-2011). Three groups were assessed: stage I/II, resected stage III and unresectable stage III/stage IV. The median follow-up time of living patients was 43.48 ± 19.67 (15-142) months. We observed a high diagnostic accuracy in all stages (91.3%, 92.5% and 96.2% respectively). PET/CT appeared to be reliable diagnostic tool even for the detection of small lymph node metastases. PET/CT was informative in 14 of 19 cases wherein another imaging examination provided inconclusive results regarding lesion dignity. However, PET/CT was less suitable for properly evaluating the dignity of a lung lesion. A true positive scan was twice as likely in clinically negative patients with resected stage III disease than in patients with stage I/II disease ...Continue Reading

References

Jul 27, 2001·Journal of Surgical Oncology·J D WagnerG Hutchins
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J ReinhardtThomas Tüting
Jan 17, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christina PfannenbergHeinz P Schlemmer
Feb 14, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Felix M MottaghySven N Reske
Mar 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Klaus StrobelHans C Steinert
Aug 19, 2007·The Journal of International Medical Research·C AkcaliE Sahin
Aug 30, 2008·Annals of Nuclear Medicine·Kazuhiro KitajimaKazuro Sugimura
Jan 22, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Patrick Veit-HaibachGerald Antoch
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Esther BastiaannetHarald J Hoekstra
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Sep 22, 2010·Nuclear Medicine Communications·Elba C S Camargo EtchebehereEdwaldo E Camargo
Oct 19, 2011·Journal of Skin Cancer·Dianne E Godar
Jun 2, 2012·Dermatology Research and Practice·Rodrigo ArrangoizJeffrey M Farma
Jul 18, 2012·European Journal of Nuclear Medicine and Molecular Imaging·E BastiaannetH J Hoekstra
Jul 24, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E EmriE Remenyik
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray

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Citations

Jan 20, 2017·Contrast Media & Molecular Imaging·Afsaneh LahootiSaeed Shanehsazzadeh
Jul 2, 2019·The Cochrane Database of Systematic Reviews·Jacqueline DinnesUNKNOWN Cochrane Skin Cancer Diagnostic Test Accuracy Group
Dec 25, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J A Avilés IzquierdoE Mercader Cidoncha

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