Abstract
The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Patients with chronic viral hepatitis (n=101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (-3.13+0.017×MMP2-0.019×haptoglobin and -0.270+0.007×HA-0.018×haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p=0.03), MMP2 (0.72/0.63, p=0.04), HA (0.79/0.76, p=0.94), Apo-A1 (0.56/0.48, p=0.73), and predictive logit-model (0.81/0.78, p=0.68) showed higher diagnostic value in the HV sample. While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
References
Sep 1, 1983·Radiology·J A Hanley, B J McNeil
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Jun 11, 2005·Endocrine-related Cancer·S Ø WürtzN Brünner
Sep 24, 2005·Journal of Hepatology·Valérie Paradis
Mar 1, 2006·BMC Gastroenterology·Vlad RatziuUNKNOWN CYTOL study group
Sep 15, 2006·Journal of Viral Hepatitis·C ChristensenB McMahon
Mar 17, 2007·Clinical Biochemistry·Liu HongboZhang Yong
Apr 3, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A GressnerAxel M Gressner
Jun 5, 2007·Clinics in Liver Disease·Ancha BaranovaZobair M Younossi
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Erika Martínez-LópezArturo Panduro
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abdel Aziz M Shaheen, Robert P Myers
Nov 9, 2007·Clinical Biochemistry·Paul CalèsFrançoise Lunel-Fabiani
Apr 25, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Manoj KumarShiv K Sarin
May 13, 2008·Gastroenterology·Scott L Friedman
Aug 5, 2008·Journal of Viral Hepatitis·H L-Y ChanV W-S Wong
Sep 12, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Gianluca Svegliati-BaroniMarco Marzioni
Dec 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sylvie NaveauThierry Poynard
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yusuf YilmazEnver Dolar
Mar 24, 2009·Journal of Hepatology·Ming-Hung TsaiCheng-Shyong Wu
Sep 3, 2009·Nature Reviews. Gastroenterology & Hepatology·Jaime BoschJuan Carlos García-Pagan
Oct 31, 2009·Journal of Viral Hepatitis·T J S CrossP M Harrison
Feb 13, 2010·Journal of Hepatology·Luc GailhousteGeorges Baffet
Feb 26, 2010·Alimentary Pharmacology & Therapeutics·G L H WongH L Y Chan
Mar 23, 2010·Trends in Molecular Medicine·Matthew L CowanSanjeev Krishna
Apr 13, 2010·Clinical Biochemistry·N BarascukM A Karsdal
Apr 30, 2010·Digestive Diseases and Sciences·Myoung Hee LeeSung Won Cho
May 4, 2010·Clinical Biochemistry·Seung Ha ParkYoung Bae Kim
Aug 18, 2010·Clinical Biochemistry·Paul CalèsUNKNOWN multicentric groups (SNIFF 14 & 17, ANRS HC EP 23 Fibrostar)
Aug 31, 2010·Ultrasound in Medicine & Biology·Ji Eun KimByung Ihn Choi
Jan 17, 2012·Journal of Magnetic Resonance Imaging : JMRI·Rahul RustogiFrank H Miller
Feb 9, 2012·The Korean Journal of Hepatology·Yong Han Paik, David A Brenner
Nov 20, 2013·HIV Medicine·R SanmartínC Tural
Apr 12, 2016·Clinics in Liver Disease·Kristina R Chacko, John Reinus
Citations
Jul 21, 2015·Clinical Biochemistry·Manuela G NeumanRadu Nanau
Mar 31, 2015·Osteoarthritis and Cartilage·W E Van SpilF P J G Lafeber
Oct 8, 2016·Hepatology International·Gamal ShihaManoj Kumar
Apr 24, 2014·Clinical and Molecular Hepatology·Ki Tae Suk
Apr 8, 2015·World Journal of Hepatology·Ki Tae Suk, Dong Joon Kim