PMID: 29772626Jul 1, 1991Paper

Diagnostic accuracy of biopsy urease tests for Helicobacter pylori infection in the gastric antrum and body

The National Medical Journal of India
H H GillS R Prabhu

Abstract

The biopsy urease test detects preformed urease in Helicobacter pylori and has excellent sensitivity and specificity for antral biopsies. Similar conclusions cannot be made for biopsies from the body of the stomach as data are scant. Endoscopy was performed and biopsies taken from the antrum and body ofthe stomach of 302 patients with dyspepsia to judge the diagnostic accuracy of Christensen's urea and campylobacter-like organism tests. The sensitivity and specificity of Christensen's urea test (n=200) was 97% and 92% for the antrum, and 34% and 85% for the body respectively. The campylobacterlike organism test (n=102) had a 100% sensitivity and specificity for the antrum and a 97% sensitivity and 100% specificity for the body. It was also positive in 97% (31132) and 90% (27/30) of patients at 10 minutes and 30 minutes when the colonization was dense (grade 3), and 90% (27/30) positive at 1 to 3 hours when the density of the organisms was graded as 2. All tests positive at 24 hours (10/10) had densities of grades 1 and 2. The Christensen's urea test has excellent sensitivity and specificity in the antrum, but its sensitivity in the body is poor because of a low density of organisms. The campylobacter-like organism test is more ...Continue Reading

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