Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis

World Journal of Urology
Seong-Jang KimKeunyoung Kim

Abstract

We aimed to assess the diagnostic accuracy of C-11 choline and C-11 acetate positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging in bladder cancer (BC) patients through a systematic review and meta-analysis. The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through June 30, 2017, were searched for studies evaluating the diagnostic performance of C-11 choline and C-11 acetate PET/CT for LN staging in BC. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. Across 10 studies (282 patients), the pooled sensitivity was 0.66 (95% CI 0.54-0.75) without heterogeneity (χ2 = 12.4, p = 0.19) and a pooled specificity of 0.89 (95% CI 0.76-0.95) with heterogeneity (χ2 = 29.1, p = 0.00). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 5.8 (95% CI 2.7-12.7) and negative likelihood ratio (LR-) of 0.39 (95% CI 0.28-0.53). The pooled diagnostic odds ratio (DOR) was 15 (95% CI 6-38). In meta-regression analysis, the study design (prospective vs retrospective) was the source of the study hete...Continue Reading

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Citations

Aug 3, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Antti SalminenPeter J Boström
Mar 25, 2020·Current Opinion in Urology·Hyun Hwan Sung, Seth P Lerner
May 14, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Musab Ali KutluhanOrhan Koca
Sep 20, 2020·Diagnostics·Samuel J GalganoSoroush Rais-Bahrami
May 1, 2021·Medicina·Bartosz MałkiewiczRomuald Zdrojowy

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