Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
H SawadaT Kawamura

Abstract

To estimate the diagnostic accuracy of cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigram for detection of Parkinson disease. A cross-sectional study with index test of MIBG scintigram and reference standard of U.K. Parkinson's Disease Brain Bank Criteria was performed in 403 patients. Ratio of cardiac-to-mediastinum MIBG accumulation was determined at 20 min (early H/M) and 4 h (late H/M). Area under the receiver-operator characteristic (ROC) curve, sensitivity and specificity in detecting Parkinson disease were analyzed. Accuracy was analyzed in a subgroup of patients with disease duration of 3 years or less. Area under the ROC curve was 0.89 using either early or late H/M as a diagnostic marker (95% CI 0.85-0.92 for early H/M and 0.86-0.93 for late H/M). Sensitivity and specificity were 81.3% (76.1-85.8%) and 85.0% (77.7-90.6%) for early H/M and 84.3% (79.3-88.4%) and 89.5% (83.01-94.1%) for late H/M. In the subgroup with duration of 3 years or less, the ROC curve area, sensitivity, and specificity were 0.86 (0.79-0.92), 76.0% (64.8-85.1%), and 83.9% (71.7-92.4%) for early H/M and 0.85 (0.78-0.92), 73.3% (61.9-82.9%), and 87.5% (75.9-94.8%) for late H/M. Although diagnostic accuracy of cardiac MIBG scintigram is high, ...Continue Reading

References

Jul 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·S OrimoH Mizusawa
Jun 29, 2000·JAMA : the Journal of the American Medical Association·M Moselhi
Sep 9, 2000·Annals of Internal Medicine·D S GoldsteinR O Cannon
Sep 5, 2002·Annals of Neurology·Sheng-Ting LiDavid S Goldstein
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·S OrimoM Yokochi
Oct 24, 2003·Lancet Neurology·David S Goldstein
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Vicky Marshall, Donald Grosset
Jan 23, 2004·Brain : a Journal of Neurology·Amanda SingletonDavid S Goldstein
Jan 13, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Jörg SpiegelCarl-Martin Kirsch
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H NagayamaY Katayama
Feb 25, 2005·JAMA : the Journal of the American Medical Association·Hideyuki SawadaShun Shimohama
Jul 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Satoshi OrimoYoshikuni Mizuno
Nov 3, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Aldo QuattroneFrancesca Condino
Mar 7, 2008·Neuro-degenerative Diseases·Manfred GerlachPeter Riederer

❮ Previous
Next ❯

Citations

Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Hidenao Fukuyama
Mar 12, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giorgio TregliaGiorgio Fagioli
Jul 28, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Giorgio TregliaAlessandro Giordano
Dec 9, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A A Leite, O J M Nascimento
Jun 11, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M WatanabeA Tamaoka
Feb 3, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Apr 16, 2014·Revista española de medicina nuclear e imagen molecular·J ArbizuL Vela
Mar 5, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Africa MuxíFrancesca Pons
May 6, 2010·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·B TijeroJ J Zarranz
Dec 3, 2013·Rinshō shinkeigaku = Clinical neurology·Satoshi Orimo
Sep 30, 2015·Expert Review of Neurotherapeutics·Naomi Visanji, Connie Marras
Jun 28, 2012·Neurobiology of Disease·I FerrerA Martínez
Oct 18, 2011·Journal of the Neurological Sciences·Maria G Cersosimo, Eduardo E Benarroch
Jan 1, 2010·PET Clinics·John P Seibyl
Dec 5, 2009·Neuroimaging Clinics of North America·Klaus Tatsch
Oct 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Fabiana NovellinoAldo Quattrone
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Tomohiko NakamuraGen Sobue
May 4, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Koyo TsujikawaAkira Takahashi
Dec 10, 2015·Parkinson's Disease·Akira KatagiriSatoshi Kuwabara
Jun 20, 2015·Journal of Movement Disorders·Eun Joo Chung, Sang Jin Kim
Apr 25, 2012·Journal of Biomedicine & Biotechnology·Ling WangHong Zhang
Mar 23, 2011·Parkinsonism & Related Disorders·Julia DorschnerJörg Spiegel
Dec 3, 2016·Journal of the International Neuropsychological Society : JINS·Christine A Cooper, Lama M Chahine
Jun 26, 2014·Arquivos de neuro-psiquiatria·Marco Antonio Araujo LeiteFelipe Villela Pedras
Mar 7, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Viorica ChelbanHenry Houlden
Jan 8, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasuhiko IzumiAkinori Akaike
Jun 25, 2009·Nuclear Medicine Communications·Esa KauppilaJyrki Kuikka
Feb 26, 2019·Internal Medicine·Makoto EriguchiHideo Hara
Feb 26, 2015·Nuclear Medicine Communications·Yasuki MaruyamaReiko Kumano
Oct 27, 2015·Medicine·Luigi PetramalaClaudio Letizia
May 31, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hirofumi TakeyamaRyousuke Takahashi
Jan 4, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Elizabeth A CoonEduardo E Benarroch
Mar 24, 2020·Nihon Hoshasen Gijutsu Gakkai zasshi·Toyohiro KatoHiroyuki Tsushima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Satoshi OrimoHidehiro Mizusawa
Journal of Neurology, Neurosurgery, and Psychiatry
H NagayamaY Katayama
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
S Braune
Movement Disorders : Official Journal of the Movement Disorder Society
Jörg SpiegelUlrich Dillmann
© 2021 Meta ULC. All rights reserved