Diagnostic accuracy of computed tomography and histopathology in the diagnosis of usual interstitial pneumonia

Acta Radiologica
Trond Mogens AaløkkenVidar Søyseth

Abstract

The relative clinical benefit of histopathology and computed tomography (CT) in patients with idiopathic interstitial pneumonia (IIP) is under debate. To analyze thin-section CT features and histopathologic findings in patients with usual interstitial pneumonia (UIP) in the clinical context of idiopathic pulmonary fibrosis (IPF), and to evaluate and compare diagnostic accuracy of the two methods among patients with an appropriate spectrum of IIP. The study included 91 patients (49 men; mean age 53.2 years; median follow-up 7.2 years) with clinically suspected interstitial lung disease. All underwent surgical lung biopsy and thin-section CT. Two independent readers retrospectively assessed the CT images for the extent and pattern of abnormality and made a first-choice diagnosis. Two pathologists retrospectively assessed the histopathologic slides. In 64 patients with IIP, a retrospective composite reference standard identified 41 patients with UIP. CT characteristics of UIP and IIPs other than UIP were compared with univariate and multivariate analyses. There was good agreement between the readers for the correct first-choice CT diagnosis of UIP (κ = 0.79). The sensitivity, specificity, and positive predictive value of the CT di...Continue Reading

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Citations

Jun 2, 2015·Respiratory Medicine·Vidar SøysethAlf Kolbenstvedt
Oct 11, 2016·International Archives of Occupational and Environmental Health·Bente UlvestadMay Brit Lund
Feb 14, 2018·The American Journal of Surgical Pathology·Kati MäkeläRiitta Kaarteenaho
Jun 24, 2020·Occupational and Environmental Medicine·Bente UlvestadDag Gunnar Ellingsen
Dec 3, 2017·International Archives of Occupational and Environmental Health·Niels E KirkhusDag G Ellingsen

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Methods Mentioned

BETA
biopsy
biopsies
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Software Mentioned

STATA
SPSS

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