Diagnostic accuracy of computed tomography to identify adenomas among adrenal incidentalomas in an endocrinological population

European Journal of Endocrinology
M MartyA Tabarin

Abstract

The recent recommendations of the European Endocrine Society states that the performance of computed tomography (CT) to characterize 'true' adrenal incidentalomas (AIs) remains debatable. To determine relevant thresholds for usual CT parameters for the diagnosis of benign tumors using robust reference standard among a large series of 'true' AIs recruited in an endocrinological setting. Retrospective study of 253 AIs in 233 consecutive patients explored in a single university hospital: 183 adenomas, 33 pheochromocytomas, 23 adrenocortical carcinomas, 5 other malignant tumors and 9 other benign tumors. Reference standard was histopathology in 118 AIs, biological diagnosis of pheochromocytoma in 2 AIs and size stability after at least 1 year of follow-up in 133 AIs. Sensitivity, specificity and positive and negative predictive values were estimated for various thresholds of size, unenhanced attenuation (UA), relative and absolute wash-out (RPW, APW) of contrast media. 197 scans were reviewed independently in a blinded fashion by two expert radiologists to assess inter-observer reproducibility of measurements. Criteria associated with a 100% positive predictive value for the diagnosis of benign AI were: a combination of size and UA...Continue Reading

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Citations

Mar 1, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Anand VaidyaHans K Ghayee
Mar 27, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Dimitra A VassiliadiStylianos Tsagarakis
Apr 13, 2018·Journal of the Endocrine Society·Meng HaoAnand Vaidya
Apr 9, 2020·Endocrine Reviews·Mark SherlockPaul M Stewart
Dec 6, 2020·Annales d'endocrinologie·Sophie CambosAntoine Tabarin
Feb 18, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Nicholas Yozamp, Anand Vaidya
Nov 20, 2020·Annals of Surgical Oncology·Serkan AkbulutEren Berber
May 26, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Sophie Cambos, Antoine Tabarin
Oct 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Kristina BerkeGraeme Eisenhofer

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