Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-polydipsia Syndrome: A Prospective Multicenter Study

The Journal of Clinical Endocrinology and Metabolism
Katharina TimperM Christ-Crain

Abstract

The polyuria-polydipsia syndrome comprises primary polydipsia (PP) and central and nephrogenic diabetes insipidus (DI). Correctly discriminating these entities is mandatory, given that inadequate treatment causes serious complications. The diagnostic "gold standard" is the water deprivation test with assessment of arginine vasopressin (AVP) activity. However, test interpretation and AVP measurement are challenging. The objective was to evaluate the accuracy of copeptin, a stable peptide stoichiometrically cosecreted with AVP, in the differential diagnosis of polyuria-polydipsia syndrome. This was a prospective multicenter observational cohort study from four Swiss or German tertiary referral centers of adults >18 years old with the history of polyuria and polydipsia. A standardized combined water deprivation/3% saline infusion test was performed and terminated when serum sodium exceeded 147 mmol/L. Circulating copeptin and AVP levels were measured regularly throughout the test. Final diagnosis was based on the water deprivation/saline infusion test results, clinical information, and the treatment response. Fifty-five patients were enrolled (11 with complete central DI, 16 with partial central DI, 18 with PP, and 10 with nephrog...Continue Reading

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Citations

May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·M Christ-CrainW Fenske
Jan 23, 2016·Nature Reviews. Endocrinology·Mirjam Christ-Crain, Wiebke Fenske
May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Jonas RutishauserPeter Kopp
May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·W FenskeM Christ-Crain
Apr 28, 2016·International Journal of Endocrinology·Wendong LiuGuimei Li
Apr 5, 2016·Lancet·Claire E HighamStephen M Shalet
Oct 3, 2017·Internal Medicine Journal·Nicole NigroWarrick J Inder
Nov 11, 2017·F1000Research·Charlotte Van HerzeeleKristian Vinter Juul
Aug 15, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·William PedrosaAntônio Ribeiro-Oliveira
Oct 1, 2018·Clinical Endocrinology·Aoife GarrahyChristopher J Thompson
Feb 10, 2018·Critical Care : the Official Journal of the Critical Care Forum·Nicole NigroMirjam Christ-Crain
Dec 29, 2018·Endocrine Connections·Julie RefardtMirjam Christ-Crain
Feb 8, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Qi Qian
Sep 9, 2019·BMJ Case Reports·Eka NandoshviliNikhil Johri
Dec 1, 2019·Drug and Therapeutics Bulletin·Eka NandoshviliNikhil Johri
Aug 19, 2020·European Journal of Pediatrics·Gerdi TuliLuisa de Sanctis
Sep 7, 2019·Critical Care : the Official Journal of the Critical Care Forum·Patrick M HonoreWillem Boer
Mar 13, 2018·World Journal of Nephrology·Moomal TasneemGopala Rangan
Nov 2, 2018·The New England Journal of Medicine·Djalila Mekahli, François Jouret
Aug 10, 2019·Nature Reviews. Disease Primers·Mirjam Christ-CrainAlan S Verkman
Aug 25, 2018·Journal of the Endocrine Society·Pratima NayakLuma Ghalib
Aug 2, 2018·The New England Journal of Medicine·Clifford J Rosen, Julie R Ingelfinger
Aug 2, 2018·The New England Journal of Medicine·Wiebke FenskeMirjam Christ-Crain
Aug 2, 2019·Journal of Endocrinological Investigation·M Christ-Crain, W K Fenske
Dec 22, 2017·The Journal of Clinical Endocrinology and Metabolism·Wiebke K FenskeMirjam Christ-Crain
Apr 10, 2019·Journal of the American Society of Nephrology : JASN·Daniel G BichetDetlef Bockenhauer
Jan 27, 2020·Lancet·Bettina Winzeler, Mirjam Christ-Crain
Mar 2, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amporn VanasuntornChutintorn Sriphrapradang
Jul 28, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Martin SpiessJonas Rutishauser
Apr 1, 2021·Curēus·Cody M MutterHoang Nguyen
Mar 14, 2021·Journal of Internal Medicine·M Christ-CrainJ Refardt
May 14, 2021·Scientific Reports·Clara Odilia SailerMirjam Christ-Crain
Jun 28, 2021·Neuropeptides·Alina SăcărescuDumitru D Brănișteanu
Jul 23, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Letícia BitencourtAna Cristina Simões E Silva
Sep 13, 2021·Kidney Research and Clinical Practice·Sang Heon Suh, Soo Wan Kim
Sep 3, 2021·The Journal of Clinical Investigation·Bettina WinzelerMirjam Christ-Crain
Jan 28, 2020·Neuroendocrinology·Mirjam Christ-Crain

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