Diagnostic accuracy of CSF neurofilament light chain protein in the biomarker-guided classification system for Alzheimer's disease

Neurochemistry International
Simone ListaAlzheimer Precision Medicine Initiative (APMI)

Abstract

We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performance of CSF NFL concentration in differentiating patient groups stratified by fluid biomarker profiles, independently of the severity of cognitive impairment (mild cognitive impairment (MCI) and AD dementia individuals), using a biomarker-guided descriptive classification system for AD. CSF NFL concentrations were examined in a multicenter cross-sectional study of 108 participants stratified in AD pathophysiology-negative (both CSF tau and the 42-amino acid-long amyloid-beta (Aβ) peptide (Aβ1-42)) (n = 15), tau pathology-positive only (n = 15), Aβ pathology-positive only (n = 13), AD pathophysiology-positive (n = 33), FTD (n = 9) patients, and HCs (n = 23), according to the biomarker-based classification system. The performance of CSF NFL in discriminating AD pathophysiology-positive patients from HCs is fair, whereas the ability in differentiating tau-positive patients from HCs is poor. The classificatory performan...Continue Reading

Citations

Aug 15, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matías NiikadoEzequiel I Surace
Apr 11, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Lorenzo GaetaniHenrik Zetterberg
Mar 12, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Isabelle BosPieter Jelle Visser
Apr 24, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Andrew P MerluzziBarbara B Bendlin
Jan 13, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Harald HampelUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Harald HampelUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Nov 15, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Laura E BaldassariJeffrey A Cohen
Apr 20, 2020·Aging Clinical and Experimental Research·Eleni KarantaliIoannis Mavroudis
May 10, 2018·Frontiers in Neuroscience·Isabelle L SumnerJessica L Teeling
Nov 30, 2018·Acta Neuropathologica·José Luis MolinuevoKaj Blennow
Sep 19, 2020·Alzheimer's Research & Therapy·Manju L SubramanianThor D Stein
Jan 26, 2018·Alzheimer's Research & Therapy·Samir Abu-RumeilehPiero Parchi
Nov 17, 2017·Journal of Neural Transmission·Panagiotis AlexopoulosUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 29, 2020·Frontiers in Aging Neuroscience·Christiana BjorkliIoanna Sandvig
Nov 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katheryn A Q CousinsMurray Grossman
Nov 26, 2020·Pathogens and Disease·Thekra KhushafaZhu Haixia
Oct 5, 2019·Neurobiology of Aging·Nicola ToschiUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Feb 19, 2020·Journal of Equine Veterinary Science·Abubakar Musa MayakiAbdullah Rasedee
Feb 24, 2020·Neurobiology of Aging·Patrizia A ChiesaUNKNOWN Alzheimer Precision Medicine Initiative (APMI)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.