Diagnostic Accuracy of Cytology Smear and Frozen Section in Glioma

Asian Pacific Journal of Cancer Prevention : APJCP
Anani Aila Mat Zin, Sarah Zulkarnain

Abstract

Glioma is the commonest primary intracranial tumour and it has been the most predominant tumour in many studies. It accounts for 24.7% of all primary brain tumour and 74.6% of malignant brain tumour. Intraoperative diagnosis plays a crucial role in determining the patient management. Frozen section has been the established technique in providing rapid and accurate intraoperative diagnosis. However due to some disadvantages like ice crystal artefact, high expenditure and requirement of skilled technician, there is increase usage of cytology smear either replacing or supplementing frozen section technique. The aim of this review is to determine the diagnostic accuracy of cytology smear and frozen section in glioma and to see whether there is significant difference between those techniques. The overall diagnostic accuracy for frozen section in glioma ranging from 78.4% to 95% while for cytology smear, the diagnostic accuracy ranging from 50% to 100%. Based on certain literatures, no statistically difference was observed in diagnostic accuracy of cytology smear and frozen section. Thus, cytology smear provides an alternative method in establishing intraoperative diagnosis. Both cytology smear and frozen section are complimentary to...Continue Reading

Citations

Jul 23, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·William Mathieson, Geraldine A Thomas
Mar 25, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A Yu ErmolaevI A Medyanik
Jun 30, 2019·Journal of Cellular Physiology·Omid Reza TamtajiZatollah Asemi
Aug 24, 2019·World Neurosurgery·Victoria L Watson, Jeffrey W Cozzens
May 7, 2021·BioMed Research International·Ji ShiXi Zhao
May 22, 2020·Journal of Neurological Surgery. Part A, Central European Neurosurgery·José Pedro LavradorFrancesco Vergani

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Methods Mentioned

BETA
genotyping
biopsy

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