Diagnostic accuracy of exhaled nitric oxide in exercise-induced bronchospasm: Systematic review

Revista portuguesa de pneumologia
L A S FeitosaM C A Britto

Abstract

The gold-standard method for the diagnosis of exercise-induced bronchospasm (EIB) is an exercise test combined with spirometry. However, this test is expensive, time consuming and requires specialized equipment and trained personnel. Exhaled nitric oxide (eNO) is a fast, easy, noninvasive method for the diagnosis of EIB. The aim of the present study was to assess the accuracy of the measurement of eNO for the diagnosis of EIB through a systematic review of the literature. A search was carried out in the PubMed, Lilacs, SciELO and SCOPUS databases by two independent researchers. Fifty-six papers were found. Following the application of the eligibility criteria to the title, abstract and text, six papers remained for analysis. There was a significant heterogeneity in sex (X(2)=56.44, p=0.000) and clinical spectrum (X(2)=504.00, p=0.000) between studies. In children between 3.8 and 7.8 years old a cutoff point >28ppb EIB can be ruled in and in children between 5 and 16 years old at a cutoff point <20EIB can be ruled out. For adults a cutoff point <7EIB can be ruled out and it can be ruled in with a cutoff point >12. Four papers reported negative predictive values above 88%. The measurement of eNO seems to be effective for ruling i...Continue Reading

References

Dec 16, 1991·Biochemical and Biophysical Research Communications·L E GustafssonS Moncada
Aug 9, 2003·Chest·Samy M ElHalawaniDennis E Amundson
Dec 8, 2004·Immunology and Allergy Clinics of North America·William W Storms
Apr 17, 2007·The Journal of Allergy and Clinical Immunology·John M WeilerUNKNOWN Ad Hoc Committee of Sports Medicine Committee of American Academy of Allergy, Asthma & Immunology
Apr 17, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Michel RamserDaniel Trachsel
Feb 26, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Namiko KojimaAkira Akasawa
Jun 6, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L Pekka MalmbergMika J Mäkelä

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Citations

Sep 24, 2015·The American Journal of Case Reports·Nattachai AnantasitAroonwan Preuthipan
May 29, 2012·Revista portuguesa de pneumologia·J C Winck, A Morais
Dec 3, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S E HarnanR Lawson
Feb 21, 2014·Expert Review of Respiratory Medicine·Oliver J PriceLes Ansley

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