Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D L MandellM L Urken

Abstract

To assess the diagnostic accuracy of fine-needle aspiration (FNA) and frozen section (FS) in nodular thyroid disease. Tertiary care academic medical center. Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS sensitivity, specificity, and accuracy were calculated with respect to permanent section histology. Among 63 patients with an FNA interpreted as either benign (n = 38) or malignant (n = 25), FNA was accurate (sensitivity 89%, specificity 97%, accuracy 94%). FS identified only one case of carcinoma missed by FNA. Among 76 patients with a "suspicious" FNA, FS was reasonably accurate (sensitivity 67%, specificity 100%, accuracy 89%), but was deferred in 50% of cases. Given high FNA accuracy, more selective use of FS is suggested. The study results will assist with intra-institutional patient counseling and intraoperative decision-making with respect to FNA and FS results in patients with nodular thyroid disease.

References

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Nov 11, 1998·Journal of the American College of Surgeons·L A BoydJ B Hanks

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Citations

Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F LumachiG Favia
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Matthew C MillerEdmund A Pribitkin
Feb 13, 2013·International Journal of Otolaryngology·Russel KahmkeRamon M Esclamado
Mar 3, 2005·American Journal of Otolaryngology·Francis P RuggieroBrendan C Stack
Jan 22, 2010·World Journal of Surgery·Anna E BargrenStan B Sidhu
Nov 26, 2009·The Journal of Surgical Research·Adam J SchiroRebecca S Sippel
Sep 11, 2010·The Journal of Surgical Research·Xiaoqing ZhangZhi Xu
Dec 16, 2005·Diagnostic Cytopathology·Helen H Wang
Dec 31, 2003·Annals of Surgical Oncology·Rachael A CallcutHerbert Chen
Nov 17, 2019·American Journal of Clinical Pathology·Jhorman Grisales, Alvaro Sanabria
Nov 22, 2018·Archives of Endocrinology and Metabolism·Leila AghaghazviniMajid Assadi

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Methods Mentioned

BETA
biopsy
biopsies

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