Diagnostic Accuracy of Glaucoma With Sector-Based and a New Total Profile-Based Analysis of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness

Investigative Ophthalmology & Visual Science
Vishva M DanthurebandaraBalwantray C Chauhan

Abstract

To compare the diagnostic accuracy of conventional sector-based analysis with a method devised to detect the smallest localized neuroretinal rim and retinal nerve fiber layer thickness (RNFLT) damage. One eye of 151 glaucoma patients and 83 healthy controls (median age and MD, 71.7 and 66.7 years, and -3.6 and -0.3 dB, respectively) was imaged with spectral-domain optical coherence tomography (OCT). Bruch's membrane opening-minimum rim width (BMO-MRW) and RNFLT were determined at 1° intervals and also averaged for each sector. A classification of glaucoma was made with sectoral analysis when the sectoral value was below the 1%, 5%, or 10% normative limit (from an independent normative dataset); and with total analysis when a given number of measurements was below the 1%, 5%, or 10% normative limit. With the 1% normative limit, BMO-MRW sectoral analysis yielded sensitivity of 87% and specificity of 92%; while at the same specificity (92%), total analysis yielded sensitivity of 88%. With RNFLT, sectoral analysis yielded sensitivity of 85% and specificity of 95%; while at the same specificity (95%), total analysis yielded sensitivity of 83%. The results for the 5% and 10% normative limits yielded lower specificity but higher sensi...Continue Reading

Citations

Mar 21, 2018·European Journal of Ophthalmology·Silvio Di StasoGian Luca Scuderi
Nov 28, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M AweK Hufendiek
May 12, 2017·The British Journal of Ophthalmology·Sourabh SharmaMichael Ja Girard
May 31, 2019·The British Journal of Ophthalmology·Feihui ZhengChristopher Kai-Shun Leung
Aug 10, 2019·The British Journal of Ophthalmology·Yong Woo KimKi Ho Park
May 23, 2020·Journal of Clinical Medicine·Alfonso Parra-BlesaJose Javier Garcia-Medina
Jan 29, 2019·American Journal of Ophthalmology·Atalie C ThompsonFelipe A Medeiros

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