Diagnostic accuracy of guided cervical biopsies: a prospective multicenter study comparing the histopathology of simultaneous biopsy and cone specimen

American Journal of Obstetrics and Gynecology
Christian ZuchnaAlfons Staudach

Abstract

We sought to determine the validity of colposcopically directed cervical biopsies as a diagnostic test to define the degree of cervical intraepithelial neoplasia (CIN). In a prospective multicenter trial, patients undergoing excisional procedures of the transformation zone additionally had colposcopy and up to 3 guided cervical biopsies in a single procedure. Cervical biopsies were regarded as a diagnostic test to detect high-grade lesions (CIN 2,3), with the cone specimen as reference standard. In all, 488 biopsies were performed in 244 cases, with 2 biopsies done in 192 cases. Cervical biopsies underestimated the severity of lesions in 46.7% of cases. Sensitivity, specificity, and positive and negative predictive values were 66.2% (95% confidence interval [CI], 59.4-72.3), 95.0% (95% CI, 83.5-98.6), 98.5% (95% CI, 94.8-99.6), and 35.5% (95% CI, 27.1-44.9), respectively. Our data suggest that cytologically suspected high-grade lesions (CIN 2,3) can be confirmed by biopsy in many cases, but they cannot be excluded.

References

Dec 1, 1991·British Journal of Obstetrics and Gynaecology·E J BuxtonM Rollason
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·M SkehanJ Pryse-Davies
Jan 1, 1980·British Journal of Obstetrics and Gynaecology·W Kirkup, A S Hill
Jul 1, 1995·British Journal of Obstetrics and Gynaecology·L A DennyB Bloch
Mar 1, 1996·Gynecologic Oncology·L S MassadP Bitterman
Feb 18, 1998·American Journal of Obstetrics and Gynecology·M SpitzerM Ryskin
Mar 23, 2001·JAMA : the Journal of the American Medical Association·M H StolerUNKNOWN Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group
Nov 1, 1993·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M.P.M. Burger, H. Hollema
Jan 1, 2003·Clinical Chemistry·Patrick M BossuytUNKNOWN Standards for Reporting of Diagnostic Accuracy
May 6, 2004·JAMA : the Journal of the American Medical Association·Lynn SadlerLesley McCowan
Sep 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Björn StranderThomas Rådberg
May 9, 2006·American Journal of Obstetrics and Gynecology·Jose Jeronimo, Mark Schiffman
Aug 2, 2006·Obstetrics and Gynecology·Julia C GageUNKNOWN ASCUS LSIL Triage Study (ALTS) Group
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
May 23, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·K J DentonUNKNOWN British Society of Clinical Cytology
Dec 2, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·J JordanW Prendiville
Dec 2, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·V Wadehra, S J Johnson
May 30, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Zhi Gang LiYan Hong Shu

❮ Previous
Next ❯

Citations

Dec 10, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pluvio J Coronado, María Fasero
Dec 22, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Kine PedersenIvar Sønbø Kristiansen
Aug 14, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·M UnderwoodE L Moss
May 11, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·E MossM Arbyn
Apr 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·George KoliopoulosDimitrios Kassanos
Apr 17, 2013·Journal of Medical Virology·Sonia Perez CastroMaría Oña Navarro
Apr 8, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Mette T RoensboJan Blaakaer
Nov 19, 2014·PloS One·Sveinung Wergeland SørbyeFinn Egil Skjeldestad
Jun 7, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·K PedersenE A Burger
Oct 21, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Ingrid BaaslandPål R Romundstad
Oct 18, 2016·Journal of Lower Genital Tract Disease·Anna J Koné PéfoyoRachel Kupets
Mar 16, 2018·Journal of Lower Genital Tract Disease·Liv Reidun TverelvFinn Egil Skjeldestad
Sep 20, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ilker KahramanogluMacit Arvas
Sep 28, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Atittaya VallapapanKhwanarnong Uthagethaworn
Jun 30, 2018·Journal of Lower Genital Tract Disease·Meritxell MunmanyMarta Del Pino
Aug 28, 2020·Statistics in Medicine·Braden C SoperJan F Nygård
Oct 28, 2018·Archives of Gynecology and Obstetrics·Frederik A StuebsMartin C Koch
Jun 2, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Daniela UlrichOlaf Reich
Sep 11, 2017·Archives of Gynecology and Obstetrics·Aiping FanFengxia Xue
Dec 25, 2019·International Journal of Cancer. Journal International Du Cancer·Gaby SroczynskiUwe Siebert
Jul 7, 2012·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Ivar Sønbø Kristiansen
Oct 30, 2020·Diagnostic Cytopathology·Demet Aydogan KirmiziEthem Serdar Yalvac
Dec 31, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hongyan RenSuzhen Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.