Diagnostic accuracy of MRI in assessing tumor regression and identifying complete response in patients with locally advanced rectal cancer after neoadjuvant treatment

Abdominal Radiology
Medhat AkerT H A Arulampalam

Abstract

The diagnostic accuracy of Magnetic Resonance Imaging (MRI) in restaging locally advanced rectal cancers (LARC) after neoadjuvant chemo-radio therapy (NCRT) has been under recent scrutiny. There is limited data on the accuracy of MRI and its timing in assessing tumor regression grade (TRG) and in identifying patients with complete response (CR). NCRT seems to cause tissue inflammation and oedema which renders reading the scans difficult for radiologist. This study aims to assess the accuracy of MRI at different time intervals after NCRT in staging TRG and in identifying CR. Inter-observer agreement between 2 blinded radiologists will also be assessed. In this retrospective analysis, all patients diagnosed with LARC between January 2003 and 2014, who underwent long-course NCRT, who had at least one post-treatment MRI scan, and who underwent surgery with available pathology results are included. Histopathology staging is considered the reference standard. Accuracy of MRI in T staging and in TRG staging is assessed using weighted kappa. Accuracy, sensitivity, and specificity in identifying CR are calculated from a 2 × 2 contingency table. Inter-observer agreement between two-staging blinded radiologists is calculated using weighte...Continue Reading

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Citations

Apr 18, 2019·Abdominal Radiology·Natally HorvatIva Petkovska
Jun 12, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seong Ho ParkUNKNOWN Korean Society of Abdominal Radiology Study Group for Rectal Cancer
Jun 17, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jong Keon JangJin Cheon Kim
Aug 28, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Kirsten L Gormly

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