Diagnostic accuracy of new and old cognitive screening tools for HIV-associated neurocognitive disorders

HIV Medicine
M TrunfioA Calcagno

Abstract

Considering the similarities between HIV-associated neurocognitive disorders (HAND) and neurodegenerative dementias and the frequency of executive dysfunctions among HIV-positive patients, we evaluated the accuracy of the Frontal Assessment Battery and Clock-Drawing Test together with the Three Questions Test and International HIV Dementia Scale to screen for HAND. A cross-sectional monocentric study was conducted from 2010 to 2017. The index tests were represented by the four screening tools; the reference standard was represented by a comprehensive neurocognitive battery used to investigate 10 cognitive domains. Patients were screened by a trained infectious diseases physician and those showing International HIV Dementia Scale scores ≤ 10 and/or complaining of neurocognitive symptoms were then evaluated by a trained neuropsychologist. A total of 650 patients were screened and 281 received the full neurocognitive evaluation. HAND was diagnosed in 140 individuals. The sensitivity, specificity, correct classification rate and area under the receiver operating characteristic curve (AUROC) were, respectively, as follows: Frontal Assessment Battery, 40.7%, 95.1%, 68.3% and 0.81; International HIV Dementia Scale, 74.4%, 56.8%, 65.4%...Continue Reading

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Citations

Aug 2, 2020·Journal of Neurovirology·Ilaria De BenedettoAndrea Calcagno
Sep 4, 2018·The Annals of Pharmacotherapy·Joshua CaballeroMark S Schweizer
Oct 16, 2020·Expert Review of Anti-infective Therapy·Franco MaggioloAntonio Di Biagio
Mar 19, 2021·Revista colombiana de psiquiatría·Antonios TheofilidisJohn Nimatoudis
Jun 9, 2021·Revista Colombiana De Psiquiatría (English Ed.)·Antonios TheofilidisJohn Nimatoudis

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