Diagnostic accuracy of parathyroid hormone levels in washout samples of suspicious parathyroid adenomas: A single-centre retrospective cohort study

Clinical Endocrinology
Asena Gökçay CanpolatDemet Çorapçıoğlu

Abstract

Minimally invasive surgery is an alternative surgical approach for primary hyperparathyroidism with less surgical trauma and anaesthesia complications. When combined with intraoperative measurement of parathyroid hormone (PTH), cure rates are exceeding 97%. Preoperative intact PTH determination in washout samples is really very useful when parathyroid lesions cannot be easily distinguished from thyroid lesions or sometimes lymph nodes. Herein, we aimed to report our institutional experience about parathyroid fine-needle aspiration (FNA) method and suggest a cut-off ratio for this purpose. In our clinic, we performed ultrasonography (USG)-guided parathyroid FNA procedure for 131 patients diagnosed with primary hyperparathyroidism between January 2005 and January 2016. Both cytologic evaluation and intact PTH determination were performed in washout samples. Eighty-seven of the study group also had a parathyroid scintigraphy. Both demographic features and laboratory results were all recorded. Median serum PTH level was 142 (113-197), while mean PTH washout level was 1824 (0-3953). When three of the localization techniques are compared with each other, FNA-PTH washout group had a better diagnostic accuracy (90.8%) when compared to ...Continue Reading

References

Sep 30, 2006·Annals of Surgical Oncology·Christina MaserRobert Udelsman
Aug 3, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Devaprabu AbrahamDonald A McClain
Jul 13, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Irina BancosDiana S Dean
Aug 28, 2014·The Journal of Clinical Endocrinology and Metabolism·John P BilezikianJohn T Potts

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Citations

Apr 18, 2019·Clinical Endocrinology
Aug 25, 2020·Diagnostic Cytopathology·Ayana SuzukiAkira Miyauchi
Jun 26, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Wei ZhaoXiuzhang Lv

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