Diagnostic Accuracy of Platelet Count and Platelet Indices in Noninvasive Assessment of Fibrosis in Nonalcoholic Fatty Liver Disease Patients

Canadian Journal of Gastroenterology & Hepatology
Tamara Milovanovic AlempijevicTomica Milosavljevic

Abstract

Keeping in mind the rising prevalence of nonalcoholic fatty liver disease (NAFLD) and the need to establish noninvasive tests for its detection, the aim of our study was to investigate whether platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) can predict the presence of liver fibrosis in this group of patients. In 98 patients with NAFLD and 60 healthy volunteers, complete blood counts with automated differential counts were performed and values of PC, PDW, MPV, and PCT were analyzed. Patients with NAFLD had lower PC and higher MPV, PCT, and PDW compared to the controls (P < 0.05). When NAFLD group was stratified according to severity of liver fibrosis, there was a statistically significant difference in the average values of PDW and PC between the groups (P < 0.05). Patients with NAFLD have significantly higher values of PCT, PDW, and MPV when compared to the healthy controls. Further studies are needed to establish their potential use for prediction of the degree of liver steatosis and fibrosis in NAFLD patients.

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Citations

Jan 26, 2020·Journal of Viral Hepatitis·Jian WangChao Wu
Aug 25, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Osman UzundereSedat Kaya
Mar 27, 2020·Journal of Immunology Research·Tianyi FangYingwei Xue
Feb 13, 2021·Platelets·Pamela CzajkaCeren Eyileten
Feb 26, 2021·Disease Markers·Zhe WangZhaolan Hu
Jun 1, 2021·Disease Markers·Mattia BellanPier Paolo Sainaghi
Jun 8, 2021·Canadian Journal of Gastroenterology & Hepatology·Lubomir SkladanyTomas Koller
Aug 11, 2021·Viruses·Yashasavi SacharStephen E Congly
Sep 2, 2021·Saudi Journal of Biological Sciences·Abdulhakeem S AlamriSyed Mohammed Basheeruddin Asdaq

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
FibroTest

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