Diagnostic accuracy of polymerase chain reaction for intrapartum detection of group B streptococcus colonization

Acta Obstetricia Et Gynecologica Scandinavica
Rikke B Helmig, Jan B Gertsen

Abstract

Many pregnant women are treated with antibiotics during labor to prevent transmission of group B streptococcus (GBS, Streptococcus agalactiae) to their baby during passage of the birth canal, and so reduce the risk of serious infection of the newborn. Methods for intrapartum testing for GBS have been introduced to select women to whom intrapartum antibiotic prophylaxis should be offered. For such an intrapartum test to be useful in clinical practice, it has to be specific as well as sensitive. The aim of the present study is to evaluate the accuracy of the polymerase chain reaction (PCR) assay compared with an optimized culture method for GBS. In the period from 12 May 2015 to 18 December 2015 we collected rectovaginal swabs from 106 women in the labor ward presenting in labor between gestational week 35(+0) and 36(+6) or presenting with prelabor/preterm prelabor rupture of membranes (PROM/PPROM) for > 14 h after gestational week 34(+0) . We performed GBS culture (reference standard) and a molecular GBS test (Xpert GBS, Cepheid Ltd., Sunnyvale, CA, USA). Based on intrapartum culture, 23.6% (25/106) were colonized with GBS. Intrapartum PCR showed a colonization rate of 25.7% (27/105). The sensitivity of the test was 100% (86.28-...Continue Reading

References

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Citations

May 22, 2019·BMC Pregnancy and Childbirth·Kate ClouseNatasha Halasa
Jun 15, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Y NielsenM R Khalil
Nov 16, 2019·BMC Health Services Research·Marie Höjriis StorkholmCarl Savage
Jan 5, 2021·Maternal and Child Health Journal·Sabine PangerlSadie Geraghty
Jun 27, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Philip J SteerGopal Gopal Rao
Sep 8, 2021·Annals of Clinical Microbiology and Antimicrobials·Meng-Yi HanXu-Guang Guo

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