Diagnostic Accuracy of Serum Matrix Metalloproteinase-7 for Biliary Atresia

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Li YangShao-Tao Tang

Abstract

The diagnosis of biliary atresia (BA) remains a clinical challenge because affected infants have signs, symptoms, and serum liver biochemistry that are also seen in those with other causes of neonatal cholestasis (non-BA). However, an early diagnosis and prompt surgical treatment are required to improve clinical outcome. Recently, the relative abundance of serum matrix metalloproteinase-7 (MMP-7) was suggested to have discriminatory features for infants with BA. To test the hypothesis that elevated serum concentration of MMP-7 is highly diagnostic for BA, we determined the normal serum concentration of MMP-7 in healthy control infants, and then in 135 consecutive infants being evaluated for cholestasis. The median concentration for MMP-7 was 2.86 ng/mL (interquartile range, IQR: 1.32-5.32) in normal controls, 11.47 ng/mL (IQR: 8.54-24.55) for non-BA, and 121.1 ng/mL (IQR: 85.42-224.4) for BA (P < 0.0001). The area under the curve of MMP-7 for the diagnosis of BA was 0.9900 with a cutoff value of 52.85 ng/mL; the diagnostic sensitivity and specificity were 98.67% and 95.00%, respectively, with a negative predictive value of 98.28%. Conclusion: Serum MMP-7 assay has high sensitivity and specificity to differentiate BA from other ...Continue Reading

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Citations

Jul 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Krupa R MysoreSanjiv Harpavat
Aug 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sujit K MohantyGreg Tiao
Jan 4, 2020·Journal of Pediatric Gastroenterology and Nutrition·Norman Junge
Mar 5, 2019·F1000Research·Andrew WehrmanRebecca G Wells
Mar 4, 2021·Scientific Reports·Ken-Ichiro KonishiAkihiko Kimura
Mar 14, 2021·BMC Gastroenterology·Amna Basheer M AhmedAbdulrahman Abdullah Al-Hussaini
Jun 20, 2020·Journal of Hepatology·Rosana Ottakandathil BabuPaul Kwong Hang Tam
Jul 17, 2021·Frontiers in Pediatrics·Andrea HoFaraz A Khan
Aug 1, 2021·Pediatric Radiology·Deborah D Brahee, Brooke S Lampl
Mar 13, 2019·The Journal of Pediatrics·Sanjiv Harpavat
Oct 13, 2019·Pediatrics·Jingying JiangShan Zheng
Aug 17, 2021·Pediatrics·Phillipp HartmannKathleen B Schwarz

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Metavir
GraphPad Prism

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