Diagnostic accuracy of shear wave elastography for prediction of breast malignancy in patients with pathological nipple discharge

BMJ Open
Xiaobo GuoWanhu Li

Abstract

Pathological nipple discharge (PND) may indicate malignant breast lesions. As the role of shear wave elastography (SWE) in predicting these malignant lesions has not yet been evaluated, we aim to evaluate the diagnostic value of SWE for this condition. Prospective diagnostic accuracy study comparing a combination of qualitative and quantitative measurements of SWE (index test) to a ductoscopy and microdochectomy for histological diagnosis (reference test). Fuzhou General Hospital of Nanjing military command. A total of 379 patients with PND were finally included from January, 2011 to March 2014, after we screened 1084 possible candidates. All participants were evaluated through SWE, with qualitative parameters generated by Virtual Touch tissue imaging (VTI) and quantitative parameters generated by Virtual Touch tissue quantification (VTQ). All the patients were consented to receive a ductoscopy and microdochectomy for histological diagnosis, and the results were set as a reference test. Sensitivity and specificity of the combined VTI and VTQ of the SWE for detection of malignancy in patients with PND. The 379 participants presented with 404 lesions. The results of pathological examination showed that 326 (80.7%) of the 404 lesi...Continue Reading

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS
R

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