Diagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson's disease: A Systematic Review and Meta-analysis

Scientific Reports
Dun-Hui LiSheng-Di Chen

Abstract

A large number of articles have reported substantia nigra hyperechogenicity in Parkinson's disease (PD) and have assessed the diagnostic accuracy of transcranial sonography (TCS); however, the conclusions are discrepant. Consequently, this systematic review and meta-analysis aims to consolidate the available observational studies and provide a comprehensive evaluation of the clinical utility of TCS in PD. Totally, 31 studies containing 4,386 participants from 13 countries were included. A random effects model was utilized to pool the effect sizes. Meta-regression and sensitivity analysis were performed to explore potential heterogeneity. Overall diagnostic accuracy of TCS in differentiating PD from normal controls was quite high, with a pooled sensitivity of 0.83 (95% CI: 0.81-0.85) and a pooled specificity of 0.87 (95% CI: 0.85-0.88). The positive likelihood ratio, the negative likelihood ratio and diagnostic odds ratio were calculated 6.94 (95% CI: 5.09-9.48), 0.19 (95% CI: 0.16-0.23), and 42.89 (95% CI: 30.03-61.25) respectively. Our systematic review of the literature and meta-analysis suggest that TCS has high diagnostic accuracy in the diagnosis of PD when compared to healthy control.

References

Feb 1, 1993·Archives of Neurology·A J HughesA J Lees
Aug 14, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G D BorasioK Tatsch
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S BehnkeG Becker
Jun 30, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Luigi ZeccaGeorg Becker
Jul 23, 2005·Annals of Neurology·Christoph SchmidauerWerner Poewe
Mar 4, 2006·Brain : a Journal of Neurology·Jörg SpiegelCarl-Martin Kirsch
Jul 29, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Jürgen PrestelDaniela Berg
Jan 18, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Heike StocknerWerner Poewe
Jan 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Yu-Wen HuangRuey-Meei Wu
Apr 20, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pavel RessnerPetr Kanovský
Jun 26, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Ji Youn KimWon Yong Lee
May 13, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J M HagenahG Seidel
Jan 22, 2010·BMC Neurology·Sabine MehnertManfred Kaps
Jun 15, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Do-Young KwonKun-Woo Park
Jun 16, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Nin P S BajajAndrew J Lees
Nov 9, 2010·Journal of Neural Transmission·D BergT Arzberger
Dec 25, 2010·Parkinsonism & Related Disorders·Jung Ho RyuJong Sam Baik
Jun 1, 2011·Journal of Neural Transmission·Uwe WalterReiner Benecke
Sep 2, 2011·Journal of Neural Transmission·Krzysztof SadowskiAndrzej Friedman
Oct 8, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M O IzawaT Kondo
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Feb 3, 2012·Arquivos de neuro-psiquiatria·Rita de Cássia Leite FernandesDaniela Berg
Aug 28, 2012·Journal of Neurology·Panteha FathiniaAlbert C Ludolph
Oct 16, 2012·Parkinsonism & Related Disorders·M J BarrettUNKNOWN LRRK2 Ashkenazi Jewish Consortium
Jan 22, 2013·Parkinsonism & Related Disorders·Nikola KresojevićVladimir S Kostić
May 22, 2013·Neuro-degenerative Diseases·Philipp MahlknechtWerner Poewe
Mar 25, 2014·Journal of Neuroinflammation·Isabella RussoElisa Greggio
Nov 27, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Araceli Alonso-CánovasUwe Walter
Dec 30, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Sinem TuncMeike Kasten
Feb 24, 2015·Folia morphologica·W AmbrosiusW Kozubski
Mar 20, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ivanka Štenc BradvicaKristina Kralik

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Citations

Nov 16, 2016·NeuroImage. Clinical·Tarja Lönnfors-WeitzelRoland Wiest
Nov 18, 2018·The European Journal of Neuroscience·Richard Nathaniel ReesAnette Schrag
May 17, 2019·The Journal of Headache and Pain·Wei-Wei TaoYu Wang
Feb 14, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Philipp MahlknechtKlaus Seppi
Jul 18, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Alessia CarocciGiuseppe Genchi
Aug 9, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela MonacoRaffaella Franciotti
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Feb 10, 2021·Harvard Review of Psychiatry·Alan A Baumeister
Feb 6, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Michaela KaiserovaPetr Kanovsky
Nov 12, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel P EisenbergEllen Sidransky

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