Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review.

BMJ : British Medical Journal
Anne-Marie CôtéLaura A Magee

Abstract

To review the spot protein:creatinine ratio and albumin:creatinine ratio as diagnostic tests for significant proteinuria in hypertensive pregnant women. Systematic review. Medline and Embase, the Cochrane Library, reference lists, and experts. Review methods Literature search (1980-2007) for articles of the spot protein:creatinine ratio or albumin:creatinine ratio in hypertensive pregnancy, with 24 hour proteinuria as the comparator. 13 studies concerned the spot protein:creatinine ratio (1214 women with primarily gestational hypertension). Nine studies reported sensitivity and specificity for eight cut-off points, median 24 mg/mmol (range 17-57 mg/mmol; 0.15-0.50 mg/mg). Laboratory assays were not well described. Diagnostic test characteristics were recalculated for a cut-off point of 30 mg/mmol. No significant heterogeneity in cut-off points was found between studies over a range of proteinuria. Pooled values gave a sensitivity of 83.6% (95% confidence interval 77.5% to 89.7%), specificity of 76.3% (72.6% to 80.0%), positive likelihood ratio of 3.53 (2.83 to 4.49), and negative likelihood ratio of 0.21 (0.13 to 0.31) (nine studies, 1003 women). Two studies of the spot albumin:creatinine ratio (225 women) found optimal cut-off...Continue Reading

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References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Nov 1, 1992·British Journal of Obstetrics and Gynaecology·S W Lindow, D A Davey
Sep 1, 1992·American Journal of Obstetrics and Gynecology·V S KuoE D Gallery
Jan 9, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S Chua, C W Redman
Feb 1, 1990·American Journal of Obstetrics and Gynecology·S FerrazzaniS Mancuso
Oct 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T T LaoY M Lam
Mar 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O T UttendorfskyL A Stolte
Dec 22, 1983·The New England Journal of Medicine·J M GinsbergS Garella
Nov 26, 1994·BMJ : British Medical Journal·K A Douglas, C W Redman
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K H QuadriJ L Holley
Nov 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M A Brown, M L Buddle
Nov 1, 1996·American Journal of Obstetrics and Gynecology·E SchiffB M Sibai
Jan 25, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·B K RinehartJ N Martin
Aug 5, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M A BrownUNKNOWN Australasian Society for the Study of Hypertension in Pregnancy
Oct 20, 2001·American Journal of Obstetrics and Gynecology·A M AdelbergD S Lambers
Apr 4, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D R HallD Grové
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M A BrownJ M Moutquin
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Helle KielerAnders Larsson
Jan 7, 2003·Annals of Internal Medicine·Patrick M BossuytUNKNOWN Standards for Reporting of Diagnostic Accuracy
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Mark G NewmanDavid F Lewis
Mar 22, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jason WaughAidan Halligan
Jul 26, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·N SomanathanA Galimberti
Jan 24, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·D M HaasM Rivera-Alsina
Sep 17, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lorna K PhelanGeorge Mangos
Feb 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Patricia ChanGregory Davis
Dec 8, 2005·Clinical Chemistry·Gary L MyersUNKNOWN National Kidney Disease Education Program Laboratory Working Group
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·A-K WikströmM Olovsson
Nov 23, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Shahrzad ZadehmodarresMasomeh Kaboosi
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A VassalottiAndrew S Levey
Dec 11, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·J MenziesP von Dadelszen
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A VassalottiLynda A Szczech

❮ Previous
Next ❯

Citations

Aug 22, 2012·Nature Reviews. Nephrology·Mark A Brown
Nov 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Clara J DayCaroline O S Savage
Jul 28, 2009·Current Opinion in Obstetrics & Gynecology·Mamoru MorikawaHisanori Minakami
Jul 26, 2012·Clinical Obstetrics and Gynecology·Mary AmesAaron B Caughey
Aug 10, 2011·The Journal of Perinatal & Neonatal Nursing·Nancy S Townsend, Susan B Drummond
Jan 29, 2011·Nephrology·Annemarie Hennessy, Angela Makris
Apr 12, 2008·BMJ : British Medical Journal·Lucy C Chappell, Andrew H Shennan
May 16, 2008·BMJ : British Medical Journal·Colin A Walsh, Laxmi V Baxi
Jul 20, 2013·BMC Pregnancy and Childbirth·Dane A De SilvaLaura A Magee
Sep 29, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina RotaTommaso Trenti
Mar 4, 2011·Srpski arhiv za celokupno lekarstvo·Višnja LežaićJelena Marinković
Jul 9, 2010·Future Cardiology·Manju ChandiramaniAndrew H Shennan
Oct 16, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daniela N VasquezPablo M Desmery
Dec 23, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Sérgio Hofmeister Martins-CostaJosé Geraldo Lopes Ramos
Aug 10, 2013·Advances in Chronic Kidney Disease·Mary L Rosser, Nadine T Katz
Aug 10, 2013·Advances in Chronic Kidney Disease·Anjali AcharyaKisra Anis
Jan 1, 2013·Kidney International Supplements
Nov 1, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Franziska Pettit, Mark A Brown
Jan 1, 2012·Pregnancy Hypertension·Duran RamsuranT Naicker
Jul 26, 2011·Advances in Chronic Kidney Disease·Michelle A Hladunewich, Franz Schaefer
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Tiina PodymowAyub Akbari
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Michelle SilasiSarosh Rana
Feb 18, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Thomas J CadeAnne Hotchin
Sep 29, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sandra A LoweJoanne M Said
Oct 29, 2014·The Journal of Clinical Hypertension·Joël Fokom-Domgue, Jean Jacques N Noubiap
Apr 26, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·K VerdonkW Visser
Jun 4, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Yavuz Emre ŞükürFeride Söylemez
Aug 2, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Evan O GreggMichael McEwan
Aug 11, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
Mar 26, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Adi HirshbergNadav Schwartz
Dec 25, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C WilkinsonJ Monaghan
Jul 5, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Laura A MageeUNKNOWN Canadian Hypertensive Disorders of Pregnancy HDP Working Group
May 7, 2015·Pregnancy Hypertension·F PettitM A Brown
Apr 5, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Beth PaynePeter von Dadelszen
Apr 22, 2016·The Journal of Obstetrics and Gynaecology Research·Yosuke BabaShigeki Matsubara
Nov 7, 2016·Obstetrics and Gynecology Clinics of North America·Anjali Acharya
Apr 20, 2017·The Journal of Obstetrics and Gynaecology Research·Yosuke BabaHisanori Minakami
Dec 23, 2017·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Rekha SachanSoniya Dheeman
Jul 9, 2014·Nature Reviews. Nephrology·Tinnakorn ChaiworapongsaRoberto Romero
Jun 15, 2018·Hypertension·Mark A BrownUNKNOWN International Society for the Study of Hypertension in Pregnancy (ISSHP)
Oct 30, 2018·British Medical Bulletin·Yao LuHong Yuan
Jan 12, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J J ReillyD C Wilson
Jan 23, 2010·Obstetrics and Gynecology·Marshall D Lindheimer, David Kanter

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