Diagnostic and clinical significance of Crohn's disease-specific pancreatic anti-GP2 and anti-CUZD1 antibodies

Clinical Chemistry and Laboratory Medicine : CCLM
Polychronis PavlidisDimitrios P Bogdanos

Abstract

Pancreatic autoantibodies (PAB) targeting GP2 and CUZD1 are Crohn's disease (CrD)-markers. The clinical significance of anti-GP2 antibodies has been assessed, but that of anti-CUZD1 remains elusive. The aim of the study was to assess the clinical utility of anti-CUZD1/anti-GP2 by novel cell-based indirect immunofluorescence (IIF) assays in CrD. A total of 212 CrD and 249 UC patients followed up at a London IBD centre were investigated to simultaneously detect PABs, anti-GP2 and anti-CUZD1 by IIF using primate pancreatic tissue, and HEK293 over-expressing CUZD1 or GP2. Overall, 88 (41.5%) CrDs compared to 26 (10.4%) UCs (p<0.001) tested positive for IgA and/or IgG anti-GP2 and/or anti-CUZD1 antibodies, while ASCA were found in 67.5% CrDs versus 19.2% UCs (p<0.0001); ASCA and/or PAB (anti-GP2 or anti-CUZD1) were detected in 76% CrD versus 34% UC patients. IgG anti-GP2 antibodies were less prevalent in L2 phenotype (p=0.002) and more prevalent in patients with stricturing disease (p=0.0418), even when a higher cut-off (≥1000 RU) was used (p=0.0396). Also, anti-GP2 IgG positive CrD patients had younger age of disease onset. IgA and/or IgG ASCA and anti-GP2 IgG antibody positive CrDs had younger onset of disease (p<0.0001), were mor...Continue Reading

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Citations

Apr 11, 2017·Current Opinion in Rheumatology·Dimitrios P Bogdanos, Lazaros I Sakkas
Jul 12, 2017·Inflammatory Bowel Diseases·Nadja RöberMartin W Laass
Mar 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Sofia FarkonaIvan M Blasutig
Sep 5, 2020·Digestive Diseases and Sciences·Michael ShpolianskyLael Werner
Jan 29, 2020·World Journal of Gastroenterology : WJG·Konstantinos GkiourasDimitrios Petrou Bogdanos
Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn
May 12, 2020·Frontiers in Medicine·Peng ChenShenghong Zhang
Jun 6, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Calen A SteinerUNKNOWN Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium

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