Diagnostic and grading accuracy of 18 F-FDOPA PET and PET/CT in patients with gliomas: a systematic review and meta-analysis

BMC Cancer
Jiarui XiaoXuelei Ma

Abstract

Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of 18F-FDOPA PET and PET/CT in patients with gliomas. PubMed, Embase, Cochrane Library and Web of Science were searched through 13 May 2019. We included studies reporting the diagnostic performance of 18F-FDOPA PET or PET/CT in glioma patients. Pooled sensitivity, specificity, and area under the summary receiver operating characteristic (SROC) curve were calculated from eligible studies on a per-lesion basis. Eventually, 19 studies were included. Across 13 studies (370 patients) for glioma diagnosis, the pooled sensitivity and specificity of 18F-FDOPA PET and PET/CT were 0.90 (95%CI: 0.86-0.93) and 0.75 (95%CI: 0.65-0.83). Across 7 studies (219 patients) for glioma grading, 18F-FDOPA PET and PET/CT showed a pooled sensitivity of 0.88 (95%CI: 0.81-0.93) and a pooled specificity of 0.73 (95%CI: 0.64-0.81). 18F-FDOPA PET and PET/CT demonstrated good performance for diagnosing gliomas and differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Further studies...Continue Reading

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Citations

Apr 18, 2020·Expert Review of Anticancer Therapy·Michael RuffJan Buckner
Oct 22, 2020·Journal of Neurology·Dimitri RenardJean Sebastien Guillamo
Sep 22, 2020·Clinical Nuclear Medicine·Betty SalguesEric Guedj
Apr 6, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·N GiraudP Vera
May 1, 2021·Radiologic Clinics of North America·Mohammad S SadaghianiLilja B Solnes
Jun 13, 2021·EJNMMI Radiopharmacy and Chemistry·Valdemar L AndersenTri Hien Viet Huynh
Jul 27, 2021·Frontiers in Medicine·Antoine GirardXavier Palard-Novello
Aug 17, 2021·Radiologic Clinics of North America·Christian MasonJason S Lewis

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