Diagnostic and prognostic impact of serum-soluble UL16-binding protein 2 in lung cancer patients.

Cancer Science
Kosuke YamaguchiEiji Shimizu

Abstract

UL16-binding protein 2 (ULBP2) is one of the ligands for NKG2D (NKG2DL). ULBP2 expression is induced in transformed cells and is recognized by immune effector cells via the activating NKG2D immunoreceptor. Soluble forms of NKG2DL have been reported in the serum of patients with several types of cancer. The present study investigated the diagnostic and prognostic significance of serum-soluble ULBP2 (sULBP2) in lung cancer patients. We used flow cytometry to evaluate the surface expression of NKG2DL by various lung cancer cells, while sULBP2 was measured using our original ELISA. In addition, the immunological effect of sULBP2 on peripheral blood mononuclear cells (PBMC) was examined by the (51) Cr release assay. We found that ULBP2 was highly expressed and that the sULBP2 level was elevated in supernatants of cultured non-small-cell lung cancer (NSCLC) cells as well as in the serum of NSCLC patients. ULBP2 levels were especially high in squamous cell carcinoma (SQ) patients. Clinical stage IIIB and IV NSCLC patients with a sULBP2 level ≥ 8.7 pg/mL showed significantly shorter survival than patients with sULBP2 <8.7 pg/mL. In multivariate analysis, a sULBP2 level ≥ 8.7 pg/mL (hazard ratio [HR], 2.13; P = 0.038) and clinical stage...Continue Reading

References

Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Sep 29, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K DohmotoJ Takahara
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helmut R SalihAlexander Steinle
Nov 5, 2002·Nature Reviews. Cancer·Mark J SmythHideo Yagita
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louise BaconJohn Trowsdale
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Lizzia RaffaghelloVito Pistoia
Aug 12, 2005·International Journal of Cancer. Journal International Du Cancer·Stefan HoldenriederHelmut Rainer Salih
Feb 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael T BorchersDavid Cosman
Mar 3, 2006·Cancer Research·Inja Waldhauer, Alexander Steinle
Apr 20, 2006·Infection and Immunity·Michael T BorchersGee W Lau
Apr 26, 2006·Cancer Immunology, Immunotherapy : CII·Stefan HoldenriederHelmut Rainer Salih
May 16, 2006·Human Immunology·Helmut Rainer SalihAlexander Steinle
May 30, 2006·Nature Immunology·Veronika GrohThomas Spies
Aug 25, 2006·International Journal of Cancer. Journal International Du Cancer·Angela MärtenJan Schmidt
Jan 16, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vera RebmannHans Grosse-Wilde
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KuraiEiji Shimizu
May 15, 2007·Nature·Brett K KaiserThomas Spies
Apr 18, 2008·The European Respiratory Journal·K KraetzelC Schulz
Apr 29, 2008·International Immunology·Béatrice Le Maux ChansacFathia Mami-Chouaib
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Helmut Rainer SalihAlexander Steinle
Jul 8, 2008·Trends in Immunology·Segundo GonzálezCarlos López-Larrea
Oct 7, 2008·Oncogene·N Nausch, A Cerwenka
Mar 12, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Goulnar KasymjanovaDavid Small
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annette PaschenSelma Ugurel
Jan 19, 2010·The Journal of Biological Chemistry·Lola Fernández-MessinaMar Valés-Gómez
Jun 12, 2010·Immunological Reviews·Marine Champsaur, Lewis L Lanier
Jan 11, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William D Travis

❮ Previous
Next ❯

Citations

Mar 13, 2014·PloS One·Ruipeng Wang, Peter D Sun
May 18, 2013·Scandinavian Journal of Immunology·G ChitadzeD Kabelitz
Aug 19, 2015·Immunological Reviews·Raphael Carapito, Seiamak Bahram
Jul 23, 2014·Oncoimmunology·Aroa Baragaño RanerosCarlos López-Larrea
Apr 9, 2014·Frontiers in Immunology·Leticia Huergo-ZapicoSegundo Gonzalez
Sep 11, 2019·Cold Spring Harbor Perspectives in Medicine·Asmaa El-KenawiBrian Ruffell
Feb 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wai-Hang LeungWing Leung
Mar 12, 2018·Current Opinion in Immunology·Payal Dhar, Jennifer D Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.