Diagnostic and prognostic implications using age- and gender-specific cut-offs for high-sensitivity cardiac troponin T - Sub-analysis from the TRAPID-AMI study.

International Journal of Cardiology
Matthias Mueller-HennessenTRAPID-AMI Investigators

Abstract

To evaluate the impact of age- and gender-specific cut-offs for high-sensitivity cardiac troponin T (hs-cTnT) compared to the general 99th percentile hs-cTnT cut-off on diagnosis and prognosis of acute myocardial infarction (AMI). 1282 unselected patients presenting to the emergency department with suspected AMI were enrolled as part of the TRAPID-AMI study. In the present sub-analysis, reclassification of AMI diagnosis was performed by comparing the general hs-cTnT cut-off of 14ng/L to previously proposed age- and gender-dependent hs-cTnT 99th percentile cut-offs (28ng/L for ≥65years, 9ng/L for female and 15.5ng/L for male patients). Patients were further clinically adjudicated into acute coronary syndrome (ACS) and non-ACS. For patients ≥65years, application of age-specified cut-offs resulted in a decrease of AMI from 29.8% to 18.3% in the entire cohort (n=557) and 54.7% to 40.9% in the ACS subcohort (n=225). Using gender-specific cut-offs, AMI-rate increased from 16.6% to 22.6% (entire cohort, n=477) and 62.6% to 71.7% (ACS subcohort, n=99) in women, whereas in men, rates decreased from 23.1% to 21.1% (entire cohort, n=805) and 48.8% to 45.9% (ACS, n=281), respectively. Age-specified cut-offs significantly reclassified patie...Continue Reading

References

Jul 25, 1991·The New England Journal of Medicine·J Z Ayanian, A M Epstein
Jul 6, 2000·Circulation·C W Hamm, E Braunwald
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Julinda MehilliAlbert Schömig
Dec 5, 2009·Clinical Chemistry·Evangelos GiannitsisHugo A Katus
Nov 17, 2010·JAMA : the Journal of the American Medical Association·Christopher R deFilippiStephen L Seliger
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Jan 12, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·A K SaengerA S Jaffe
Oct 4, 2011·Clinical Chemistry·Fred S AppleUNKNOWN IFCC Task Force on Clinical Applications of Cardiac Biomarkers
Feb 24, 2012·JAMA : the Journal of the American Medical Association·John G CantoUNKNOWN NRMI Investigators
Apr 10, 2012·The American Journal of Medicine·Affan IrfanChristian Mueller
Jun 23, 2012·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Feb 18, 2014·Journal of the American College of Cardiology·M Odette GoreJames A de Lemos
Jul 24, 2014·Circulation·Emily M BucholzHarlan M Krumholz
Dec 1, 2012·Global Heart·Kristian ThygesenHarvey D White
Jan 23, 2016·Annals of Emergency Medicine·Christian MuellerUNKNOWN TRAPID-AMI Investigators

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Citations

Aug 19, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Matthias BossardDavid Conen
Oct 19, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Magdalena KrintusGrazyna Sypniewska
Jul 14, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Petra HillingerChristian Mueller
Apr 10, 2017·Current Cardiology Reports·Anoop S V ShahNicholas L Mills
May 2, 2017·Critical Reviews in Clinical Laboratory Sciences·Marek KozinskiGrazyna Sypniewska
Nov 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Denis MonneretDominique Bonnefont-Rousselot
Dec 12, 2017·Critical Reviews in Clinical Laboratory Sciences·Aitor Alquézar-ArbéJorge Ordoñez-Llanos
Jun 21, 2017·Clinical Chemistry·Kai M Eggers, Bertil Lindahl
Nov 30, 2016·Clinical Chemistry·Louise A Cullen, Nicholas L Mills
May 12, 2020·Journal of the American Heart Association·Prerana M Bhatia, Lori B Daniels
Aug 30, 2020·European Heart Journal·Jean-Philippe ColletUNKNOWN ESC Scientific Document Group
Mar 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Simona FerraroMauro Panteghini
Jun 11, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoUNKNOWN on the behalf of the Study Group on Cardiovascular Risk Biomarkers of the Italian Society of Clinical Biochemistry (SIBioC)
Dec 1, 2016·Diagnosis·Matthias Mueller-Hennessen, Evangelos Giannitsis
Feb 6, 2020·BioMed Research International·Xi-Ying WangJian Yang
Jul 28, 2016·The Medical Journal of Australia·Constantine N Aroney, Louise Cullen
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Hendrik T Tevaearai StahelThierry P Carrel
Jul 2, 2019·Journal of Cardiovascular Medicine·Erica RoccoLuigi M Biasucci
May 26, 2018·Scientific Reports·Jes-Niels BoeckelTill Keller
Mar 30, 2019·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M VafaieE Giannitsis
Nov 13, 2018·Critical Pathways in Cardiology·Stacey J HowellNam K Tran
Oct 7, 2017·Expert Review of Proteomics·Daniel SoetkampJennifer Van Eyk
Nov 28, 2019·Cardiovascular Therapeutics·Giulio Francesco RomitiValeria Raparelli
Dec 15, 2020·Clinical Chemistry·Anna Marie Chang
Dec 19, 2017·Clinical Biochemistry·Raphael TwerenboldChristian Mueller
Mar 31, 2021·Journal of Clinical Pathology·Tejas R KalariaRousseau Gama
Jan 27, 2021·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Justin J ReaghGregory J Fermann
Jul 25, 2021·Journal of Clinical Medicine·Abass EidizadehLutz Binder
Sep 26, 2020·Journal of the American College of Cardiology·Daniel E FormanUNKNOWN Geriatric Cardiology Section Leadership Council
Dec 7, 2021·Clinical Chemistry·Li LiuPeter A Kavsak

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