Diagnostic and prognostic molecular markers in common adult gliomas

Expert Review of Molecular Diagnostics
Andreana L Rivera, Christopher E Pelloski

Abstract

The majority of primary CNS tumors in adults are comprised of gliomas (astrocytomas, oligodendrogliomas and ependymomas). The diagnosis has historically been based on the histologic appearance of these tumors. However, as molecular data have accumulated over the years, there is considerable evidence that the molecular diversity (even within the same diagnostic entity) may account for the heterogeneity of clinical outcomes, such as response to treatment, time to progression and overall survival after diagnosis. These molecular markers are becoming more useful in the field of neuro-oncology. They can assist in diagnosis, provide prognostic information and potentially predict response to therapy. Perhaps the greatest potential for these molecular aberrations is that they may represent therapeutic targets themselves. In this article, we summarize the findings of important, published biomarker studies in adult gliomas and provide an overview of the practical uses of these markers in the clinical setting, as well as the current understanding of molecular gliomagenesis.

References

Jul 1, 1992·Neurosurgery·J G CairncrossD A Ramsay
Feb 1, 1991·British Journal of Cancer·N L TuziW J Gullick
Apr 1, 1988·Annals of Neurology·J G Cairncross, D R Macdonald
Oct 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G CairncrossC Schold
Jan 1, 1993·Brain Pathology·A von DeimlingD N Louis
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·T HoshinoC B Wilson
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LeightonG Cairncross
Feb 28, 1998·The Journal of Biological Chemistry·M A AntonyakA J Wong
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Feb 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·H FujisawaH Ohgaki
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Feb 13, 2001·Physiological Genomics·J M MarkertD J Benos
Aug 16, 2001·Journal of the National Cancer Institute·J S SmithR B Jenkins
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Paul KleihuesWebster K Cavenee
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco PignattiUNKNOWN European Organization for Research and Treatment of Cancer Radiotherapy Cooperative Group
Apr 18, 2003·Oncogene·Paul S MischelStanley F Nelson
Sep 6, 2003·Cancer Letters·Katherina ShostakVadym Kavsan
Dec 4, 2003·Current Opinion in Cell Biology·Jean Paul Thiery
May 12, 2004·FEBS Letters·Charles K BrownHelena J Mauceri
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnab ChakravartiJay S Loeffler
Aug 5, 2004·Journal of Neuropathology and Experimental Neurology·Kenneth D AldapeC David James
Sep 18, 2004·Cancer Research·William A FreijeStanley F Nelson
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Maria MöllemannGuido Reifenberger
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp

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Citations

Jun 4, 2013·Neurobiology of Disease·Xiao-Qin ZhangGilberto Ka-Kit Leung

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