Diagnostic and prognostic relevance of salivary microRNA-21, -125a, -31 and -200a levels in patients with oral lichen planus - a short report

Cellular Oncology (Dordrecht)
Masoumeh MehdipourZahra Elmi Rankohi

Abstract

Oral lichen planus (OLP), a relatively common chronic inflammatory disease of the oral mucosa, is considered to be a premalignant disorder of the oral cavity. Previously, several biomarkers have been tested for their diagnostic potential. Here, we aimed to investigate the diagnostic potential of four miRNAs, miR-21, -125a, -31 and -200a, known to be involved in oral squamous cell carcinoma (OSCC) development, in the saliva of OLP patients as also their putative relation to OSCC development in these patients. Saliva samples from 30 patients with OLP were collected, 15 of whom were diagnosed with dysplasia upon histopathologic examination. In addition, 15 saliva samples from patients with OSCC and 15 saliva samples from healthy donors were collected. After RNA extraction, the respective miRNA levels were assessed by quantitative RT-PCR. We found that the miR-21 levels were significantly increased in saliva samples derived from patients with OLP, dysplastic OLP and OSCC, compared to those from healthy controls (p = 0.012, p = 0.0017 and p < 0.0001, respectively). Conversely, significant decreases in miR-125a levels were found in the OLP, dysplastic OLP and OSCC samples, compared to those from healthy controls (p < 0.0014, p < 0.00...Continue Reading

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Citations

Jan 15, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Junjun ChenGuoyao Tang
Feb 13, 2020·Journal of Clinical Medicine·Emanuela MartinaAnnamaria Offidani
Jun 5, 2020·Cellular Oncology (Dordrecht)·Fei HuangQianming Chen
Dec 22, 2019·Cells·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
Feb 10, 2021·Journal of Personalized Medicine·Maria MeniniPaolo Pesce
Aug 10, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Zhichao MengKuimei Wang

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Graph pad prism

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