Diagnostic and prognostic significance of plasma N-terminal-pro-brain natriuretic peptide in decompensated heart failure with preserved ejection fraction

Heart, Lung & Circulation
Biju PaulCarmine G De Pasquale

Abstract

Preserved ventricular function is increasingly recognised in CHF. Although, NTpro-BNP is a well-established diagnostic marker in heart failure with impaired EF, its significance in heart failure with preserved EF is unclear. NT pro-BNP is secreted from the ventricular wall and plasma levels correlate to ventricular function. This study sought to determine the diagnostic and prognostic significance of plasma NTpro-BNP in patients with preserved EF heart failure. We recruited 133 consecutive patients with decompensated HF. The primary end point was death or hospital readmission. Median (IQR) NTpro-BNP level at admission was elevated at 5043 ng/L (2693-10,784) and was significantly lower in preserved EF, 3569 ng/L (1707-6340) than in impaired EF, 6363 ng/L (3648-13,250) (P=0.001). Eight (6%) and 19 (14%) patients died after 1 and 6 months, respectively. In a regression analysis, worsening of NTpro-BNP levels after treatment was not predictive of mortality in heart failure with preserved EF (P=0.83). Levels at discharge correlated with readmission rates at 6 months in both groups, i.e. impaired (P=0.03) and preserved EF (P=0.02). NTpro-BNP is a reliable diagnostic marker of decompensation. However, in preserved EF heart failure, th...Continue Reading

References

Apr 7, 2005·Journal of Cardiac Failure·David A Kass
May 20, 2005·European Heart Journal·Karl SwedbergUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
Jan 25, 2006·The American Journal of Medicine·Roberto LatiniUNKNOWN Val-HeFT Investigators
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Francesca BursiVéronique L Roger

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Citations

Jul 27, 2014·Heart Failure Reviews·Pasqualina L SantaguidaParminder Raina
Feb 20, 2019·Australian Health Review : a Publication of the Australian Hospital Association·Clementine LabroscianoIsuru Ranasinghe
Oct 5, 2019·European Journal of Preventive Cardiology·Kanila PereraElla Zomer
Aug 18, 2021·European Journal of Preventive Cardiology·Kanila PereraElla Zomer

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