PMID: 1063591Apr 1, 1976

Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia

British Journal of Cancer
F R Balkwill, R T Oliver

Abstract

A simple liquid culture technique has been used to study peripheral blood from patients with acute myelogenous leukaemia. Evidence is presented that cells from morphologically identical types of leukaemia have differing capacity for "differentiation" from free floating blast cells into plastic-adherent phagocytic, trypsin-resistant macrophage-like cells with Fc and C3 receptors. Preliminary analysis suggests that patients whose cells have the greatest capacity for "differentiation" have a better chance of achieving complete remission.

Citations

Jan 1, 1978·American Journal of Hematology·J R HumbertA Robinson
May 1, 1977·The Journal of Pathology·F R BalkwillW G Spector
Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·F R Balkwill, R T Oliver

Related Concepts

Cell Adhesion
Cell Differentiation Process
Cell Survival
Complement C3 precursor
Immunoglobulin Fc Fragments
Leukocytes
M Phase, Mitotic
Phagocytes
Phagocytosis
Trypure

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