Diagnostic and Prognostic Significance of Radiologic Node-positive Renal Cell Carcinoma in the Absence of Distant Metastases: A Retrospective Analysis of Patients Undergoing Nephrectomy and Lymph Node Dissection

Journal of Korean Medical Science
Hye Won LeeHyun Moo Lee

Abstract

The aim of this study was to evaluate the diagnostic and prognostic value of clinical-positive nodes at preoperative imaging (cN1) in patients with non-metastatic renal cell carcinoma (RCC) treated with lymph node dissection (LND). We retrospectively reviewed data for a cohort of 440 consecutive patients (cN0, 76.8%; cN1, 23.2%) with cTanyNanyM0 RCC who underwent nephrectomy and LND from 1994 to 2013. Metastasis-free survival (MFS) and cancer-specific survival (CSS) were estimated using the Kaplan-Meier method. Multivariate Cox regression analysis was performed to determine significant predictors of MFS and CSS. The mean number of lymph nodes (LNs) examined for all patients was 8.3, and pN1 disease was identified in 31 (7.0%). LN staging by preoperative imaging had a sensitivity of 65%, a specificity of 80%, and an accuracy of 77%. During a median follow-up of 69 months, 5-yr MFS and CSS were 83.6% and 91.3% in patients with cN0 and 49.2% and 70.1% in patients with cN1, demonstrating a trend toward worse prognosis with radiologic lymphadenopathy (all P < 0.001). Furthermore, differences in MFS and CSS between the cN0pN0 and cN1pN0 groups were significant (all P < 0.001). Clinical nodal involvement is an important determinant of...Continue Reading

References

May 29, 2003·The Journal of Urology·Allan J PantuckArie S Belldegrun
Aug 11, 2007·International Journal of Cancer. Journal International Du Cancer·Georg C HuttererPierre I Karakiewicz
May 21, 2008·Cancer·Christopher J KanePeter R Carroll
Oct 14, 2008·European Urology·Urs E Studer, Frédéric D Birkhäuser
Nov 11, 2008·The Urologic Clinics of North America·Bradley C Leibovich, Michael L Blute
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 23, 2011·The Journal of Urology·Jared M WhitsonMaxwell V Meng
Nov 3, 2011·The Urologic Clinics of North America·Scott E DelacroixChristopher G Wood
Apr 25, 2012·Annals of Surgical Oncology·Max KatesMichael A Palese
Jun 19, 2012·BJU International·Umberto CapitanioRoberto Bertini
Oct 9, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Maxine SunPierre I Karakiewicz
Jan 29, 2013·The Journal of Urology·Manuel S EisenbergBradley C Leibovich

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Citations

Nov 9, 2016·Journal of Korean Medical Science·Ho Won KangUNKNOWN KOrean Renal Cell Carcinoma (KORCC) Group
Aug 31, 2019·Expert Review of Anticancer Therapy·Armando StabileAlberto Briganti
Jul 27, 2018·World Journal of Urology·Fabio MuttinUmberto Capitanio

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Methods Mentioned

BETA
dissection
imaging techniques
X-ray
surgical resection

Software Mentioned

SPSS

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