Diagnostic and prognostic value of HE4 in female patients with primary peritoneal carcinoma

The International Journal of Biological Markers
Dong Mi, Yue-Xiang Zhang

Abstract

HE4 is a useful tumor marker for the diagnosis of ovarian, endometrial, and fallopian tube carcinoma. The aim of our study was to investigate the value of serum HE4 compared with CA125 in the diagnosis of primary peritoneal carcinoma and the estimation of treatment response and recurrence. Serum HE4 and CA125 concentrations were measured in both primary peritoneal carcinoma patients and benign gynecological disease controls. The treatment response and recurrence were assessed by serum HE4 and CA125 levels in primary peritoneal carcinoma patients. Serum HE4 and CA125 levels were significantly increased in primary peritoneal carcinoma patients compared with benign disease controls ( P<0.001). Compared with CA125, HE4 had lower sensitivity (84.2% vs. 94.7%), but higher specificity (99.2% vs. 85.3%); the combination of HE4 and CA125 led to higher sensitivity and specificity. In the receiver operating characteristic analysis, the area under the curve was 0.956 for HE4, for CA125 was 0.953, for HE4+CA125 was 0.979. Furthermore, HE4 and CA125 were closely associated with treatment response, and our results indicated that primary peritoneal carcinoma patients displayed a larger drop of HE4 compared with CA125 (75.8% vs. 61.5%). Combine...Continue Reading

References

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Jun 17, 2016·The Journal of Obstetrics and Gynaecology Research·Dong MiShu-Qin Chen

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Citations

Oct 29, 2019·Cancer Biomarkers : Section a of Disease Markers·Lv MingCuilan Zhang
Feb 9, 2020·Archives of Gynecology and Obstetrics·Dong Mi, Yuexiang Zhang
Nov 5, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Dong MiShuqin Chen

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