Diagnostic and prognostic value of interleukin-6 and C-reactive protein in community-acquired pneumonia

Scandinavian Journal of Infectious Diseases
A OrtqvistM Kalin

Abstract

The diagnostic and prognostic value of admission serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) was investigated in 203 hospital-treated patients with community-acquired pneumonia (CAP). In serum samples obtained during the first 24 h after admission, IL-6 was detectable in 198 patients (98%), with a median value of 50 ng/l. Ten % of the patients had IL-6 values of 1000 ng/l. A clear positive correlation between IL-6 and CRP was found (r = 0.29, p < 0.0001). Patients with high IL-6 or CRP levels had longer duration of fever, longer hospital stay, and had less often recovered clinically or radiographically on follow-up weeks after discharge. A high IL-6, but not a high CRP, also seemed to be associated with a higher mortality. Bacteremic pneumococcal pneumonia had the highest levels of IL-6 (mean 2852 and median 420 ng/l) and CRP (mean 292 and median 285 mg/l). High IL-6 values were also seen in patients with non-bacteremic pneumococcal pneumonia, while all patients with pneumonia due to other bacterial, or viral, aetiology had IL-6 levels of < or = 300 ng/l. In conclusion, IL-6 and CRP are promising diagnostic and prognostic tools in the management of CAP. Further studies are needed to establish the usefulnes...Continue Reading

Associated Clinical Trials

Oct 26, 2017·GILBERG SERGE

References

Jun 1, 1991·Annals of Hematology·J Bauer, F Herrmann
Sep 15, 1991·Annals of Internal Medicine·B M FarrM J Fisch
Jul 1, 1991·Respiratory Medicine·M A WoodheadI Williams
Jun 20, 1990·The American Journal of Medicine·P C Johnson, C D Ericsson
Jul 1, 1989·Reviews of Infectious Diseases·T J MarrieL Yates
Jan 1, 1987·The Journal of Infection·Y KerttulaP H Mäkelä
Jul 1, 1994·The Pediatric Infectious Disease Journal·M BensonC Svanborg
Jan 1, 1993·Scandinavian Journal of Infectious Diseases·L O HanssonL Lindquist
Mar 1, 1993·The British Journal of Surgery·R G MolloyM L Rodrick

❮ Previous
Next ❯

Citations

Jun 23, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S PadronesJ Dorca
Aug 27, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LacomaJ Domínguez
Dec 13, 2000·European Journal of Internal Medicine·A Castro-GuardiolaF Garcia-Bragado
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Oct 3, 1999·Critical Care Medicine·M S Niederman, Q A Ahmed
Jun 28, 2005·BMJ : British Medical Journal·Victor van der MeerWillem J J Assendelft
Nov 20, 2001·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee
Dec 17, 2009·Mediators of Inflammation·Hanssa Summah, Jie-Ming Qu
Apr 3, 2008·The Journal of Clinical Investigation·J Anthony G ScottE Kim Mulholland
Jan 26, 2006·BMC Infectious Diseases·Ulla HohenthalPirkko Kotilainen
Mar 17, 2011·Critical Care : the Official Journal of the Critical Care Forum·Silvia Fernández-SerranoFrederic Manresa
Jan 20, 2006·Critical Care : the Official Journal of the Critical Care Forum·Eric M MortensenJacqueline Pugh
Feb 20, 2008·Critical Care : the Official Journal of the Critical Care Forum·Djamel MokartBenoit P Guery
Dec 18, 2013·American Journal of Respiratory Cell and Molecular Biology·Bryan D KraftKaren Welty-Wolf
Feb 22, 2013·Current Opinion in Infectious Diseases·Marcos I RestrepoAntonio Anzueto
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·L MolinosJ Martinez
Dec 31, 2011·The American Journal of the Medical Sciences·Masafumi HorieYoshio Sakamoto
Feb 4, 2016·International Journal of Molecular Sciences·Kok-Khun YongShun-Fa Yang
Apr 14, 2004·Chest·Jordi AlmirallUNKNOWN Community-Acquired Pneumonia Maresme Study Group
Apr 14, 2004·Chest·Carlos M Luna
Dec 17, 2009·International Journal of Antimicrobial Agents·Esther Calbo, Javier Garau
Oct 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Josselin Le BelUNKNOWN ESCAPED study group
Apr 2, 2005·Clinics in Chest Medicine·Jane C Deng, Theodore J Standiford
Nov 24, 2004·Infectious Disease Clinics of North America·Eva Aagaard, Ralph Gonzales
Mar 29, 2011·Archives of Gerontology and Geriatrics·Zeev ArinzonYitshal Berner
Jun 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K O GradelH C Schønheyder
Jun 25, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·U HohenthalP Kotilainen
Feb 26, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M R BacciF L A Fonseca
Mar 17, 2004·Current Opinion in Infectious Diseases·Wei Shen Lim, John T Macfarlane
Aug 2, 2006·Clinical and Experimental Immunology·M Perez-CastellanoN Matamoros
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Natividad BenitoJosé M Gatell
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Silvia Fernández-SerranoFrederic Manresa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.