Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jinping FanLiguo Yin

Abstract

In response to reactive oxygen species (ROS), thioredoxin and DJ-1 are upregulated to counteract the detrimental effect of ROS under normal condition. However, cancer cells can take advantage of thioredoxin and DJ-1 against ROS-induced cell damage. In several human cancer types, thioredoxin and DJ-1 were found to be overexpressed. The present study aimed to explore the serum levels of thioredoxin and DJ-1 in non-small cell lung cancer (NSCLC) patients and its relationship to the diagnosis and prognosis of this particular malignancy. Sera from 134 NSCLC patients and 168 healthy controls were obtained. Using the enzyme-linked immunosorbent assay (ELISA) method, the levels of serum thioredoxin and DJ-1 were measured and correlated to the clinicopathological characteristics of NSCLC patients. The diagnostic and prognostic significance of the biomarkers were evaluated by using receiver operating curve (ROC), Kaplan-Meier curve, and log-rank analyses and the Cox proportional hazard model, respectively. Serum thioredoxin and DJ-1 levels were significantly higher in the NSCLC patients than that in the controls (23.5 ± 6.57 vs. 13.8 ± 2.49 and 7.11 ± 2.02 vs. 5.18 ± 1.26, respectively). NSCLC patients at later stage cancer showed signif...Continue Reading

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Citations

Feb 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinmei LuoLaisheng Li
Apr 5, 2017·Journal of Clinical Laboratory Analysis·Marco BenatiGiuseppe Lippi
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Binbin HanWei Cui
Jul 8, 2017·Proteomes·Ida Pucci-MinafraSalvatore Minafra
May 6, 2019·Journal of Bioenergetics and Biomembranes·Ludmila P DolgachevaAndrey Y Abramov
Sep 4, 2020·Oxidative Medicine and Cellular Longevity·Mayara Dos Santos MaiaFrancisco Jaime B Mendonça-Junior
Oct 21, 2017·Clinical Proteomics·Kristin L M BoylanAmy P N Skubitz
Feb 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Laura TorresanoJosé M Cuezva

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