Diagnostic and Prognostic Value of the Combination of Two Measures of Verbal Memory in Mild Cognitive Impairment due to Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Isabel SalaAlberto Lleó

Abstract

Episodic memory impairment is the core feature of typical Alzheimer's disease. To evaluate the performance of two commonly used verbal memory tests to detect mild cognitive impairment due to Alzheimer's disease (MCI-AD) and to predict progression to Alzheimer's disease dementia (AD-d). Prospective study of MCI patients in a tertiary memory disorder unit. Patients underwent an extensive neuropsychological battery including two tests of declarative verbal memory: The Free and Cued Selective Reminding Test (FCSRT) and the word list learning task from the Consortium to Establish a Registry for Alzheimer's disease (CERAD-WL). Cerebrospinal fluid (CSF) was obtained from all patients and MCI-AD was defined by means of the t-Tau/Aβ1-42 ratio. Logistic regression analyses tested whether the combination of FCSRT and CERAD-WL measures significantly improved the prediction of MCI-AD. Progression to AD-d was analyzed in a Cox regression model. A total of 202 MCI patients with a mean follow-up of 34.2±24.2 months were included and 98 (48.5%) met the criteria for MCI-AD. The combination of FCSRT and CERAD-WL measures improved MCI-AD classification accuracy based on CSF biomarkers. Both tests yielded similar global predictive values (59.9-65.3...Continue Reading

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Citations

Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel AlcoleaAlberto Lleó
Oct 7, 2018·Neurology·Ignacio Illán-GalaAlberto Lleó
Jun 12, 2018·Journal of Alzheimer's Disease : JAD·Estrella Morenas-RodríguezAlberto Lleó
Jul 28, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giulia GrandeSimone Pomati
May 28, 2019·Scientific Reports·Estrella Morenas-RodríguezAlberto Lleó
Dec 4, 2019·Annals of Clinical and Translational Neurology·Ignacio Illán-GalaAlberto Lleó
Oct 4, 2020·Alzheimer's Research & Therapy·Sylvain LehmannUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Mar 1, 2019·Molecular & Cellular Proteomics : MCP·Alberto LleóOlivia Belbin
May 14, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marina BoccardiUNKNOWN Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders (https://nextcloud.dzne.de/in

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
FCSRT
CERAD

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