Diagnostic and Therapeutic Differences Between Immune Checkpoint Inhibitor-Induced and Idiopathic Bullous Pemphigoid: A Cross-Sectional Study

The British Journal of Dermatology
G E MolinaS T Chen

Abstract

Bullous pemphigoid (BP) is a serious, rare complication from immune checkpoint inhibitors (ICIs). While most dermatologic immune-related adverse events (irAEs) present early and are mild, ICI-induced BP (ICI-BP) manifests months into therapy and can prompt ICI discontinuation and severe immunosuppression. Following irAE management guidelines, providers rely on systemic corticosteroids - which, at high doses, may confer poorer oncologic outcomes for ICI patients. Our study aims to identify diagnostic and therapeutic differences between ICI-BP and idiopathic BP (iBP) to assist providers in prompt recognition and management of this skin toxicity.

References

Nov 20, 2016·Journal of Cutaneous Pathology·Jonathan L CurryVictor G Prieto
Mar 30, 2017·JAMA Dermatology·Laura SowerbyNicole R LeBoeuf
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Apr 10, 2018·International Journal of Dermatology·Adriana T LopezLarisa Geskin
Mar 17, 2020·Acta Dermato-venereologica·Matthew J VerheydenDédée F Murrell

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Citations

Jul 6, 2020·Dermatologic Therapy·Nicolas KlugerKatriina Lappalainen
Jan 28, 2022·Nature Reviews. Clinical Oncology·Douglas B JohnsonJustin M Balko

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Bullous Pemphigoid

Bullous pemphigoid is a rare immune system disorder and skin condition that causes large, fluid-filled blisters. Bullous pemphigoid commonly affects older adults and appears in areas such as the lower abdomen, upper thighs or armpits. Discover the latest research on bullous pemphigoid here.

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