Diagnostic and therapeutic dilemma associated with atypical glandular cells on liquid-based cervical cytology

Cytopathology : Official Journal of the British Society for Clinical Cytology
K ChummunG Flannelly

Abstract

In 2008, the management of women in Ireland with atypical glandular cells changed to immediate referral to colposcopy. The optimal management of these women is unclear. A balance between the detection of occult disease and overtreatment is required. Our study aim was to document the experience of this policy at the National Maternity Hospital, Dublin. Information from the computerized data management system was analysed with the statistical package SPSS. In 2009, 156 women attended colposcopy following a single atypical glandular cell diagnosis on liquid-based cytology. The mean age was 41 years. Thirty (19.2%) women had abnormal vaginal bleeding, 31 (19.9%) were smokers and 34 (21.8%) had received previous treatment. The colposcopy was satisfactory in 125 (80.1%) and unsatisfactory in 31 (19.9%). Cervical histology was available for 146 (93.6%) women: 57 excisional procedures and 89 diagnostic biopsies. Abnormal histology was detected in 46 women (31.5%). Four women (2.7%) had invasive cancer, five (3.4%) had adenocarcinoma in situ, 21 (14.4%) had cervical intraepithelial neoplasia (CIN) grade 2 or 3 and 16 (11.0%) had CIN1. No abnormality was detected in 100 women (68.5%), including 35 (61.4%) of those who had undergone excis...Continue Reading

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Citations

Feb 13, 2013·Pain Research and Treatment·Joel S Goldberg
Jan 15, 2015·International Journal of Cancer. Journal International Du Cancer·Freija VerdoodtMarc Arbyn
Dec 28, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·L C M AmkreutzR F P M Kruitwagen

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