PMID: 25773809Mar 17, 2015Paper

Diagnostic and therapeutic implications of the vascular endothelial growth factor family in cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Syeda Kiran RiazMuhammad Faraz Arshad Malik

Abstract

Cancer progression is attained by uncontrolled cell division and metastasis. Increase in tumor size triggers different vascular channel formation to address cell nutritional demands. These channels are responsible for transferring of nutrients and gaseous to the cancer cells. Cancer vascularization is regulated by numerous factors including vascular endothelial growth factors (VEGFs). These factors play an important role during embryonic development. Members included in this group are VEGFA, VEGFB, VEGFC, PIGF and VEGFD which markedly influence cellular growth and apoptosis. Being freely diffusible these proteins act in both autocrine and paracrine fashions. In this review, genetic characterization these molecules and their putative role in cancer staging has been elaborated. Prognostic significance of these molecules along with different stages of cancer has also been summarized. Brief outline of ongoing efforts to target hot spot target sites against these VEGFs and their cognate limitations for therapeutic implications are also highlighted.

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Citations

Mar 21, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zhe WangMargot Zöller
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Tijen Temiz KayaGokhan Koyluoglu
Jul 27, 2021·Frontiers in Pharmacology·Laeza Alves SampaioAdriana Gibara Guimarães

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