Diagnostic and Therapeutic Long-term Management of Eosinophilic Esophagitis- Current Concepts and Perspectives for Steroid Use

Clinical and Translational Gastroenterology
Thomas GreuterDavid A Katzka

Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus, which requires short- and long-term treatment. In addition, patients under long-term treatment for any chronic condition should have a structured follow-up. The mainstays in EoE treatment are drugs (such as swallowed topical corticosteroids [STC] and proton pump inhibitors), dietary exclusions, and endoscopic dilations. STC are the most widely used treatment and have proven efficacy in inducing clinical, endoscopic and histological remission in active EoE. However, data regarding maintaining disease remission and long-term management are limited. Ongoing disease activity and relapses despite STC treatment are frequently observed. This sheds light on the urgent need for adequate maintenance strategies, which have not been well defined. In terms of follow-up concepts, to date neither guidelines nor consensus recommendations have been published. To summarize the current knowledge on long-term diagnostic and therapeutic STC management of EoE, we conducted a literature search using PubMed and Embase applying the following key search items: Eosinophilic esophagitis, eosinophils, esophagus, swallowed topical corticosteroids, fluticasone, budesonide, lon...Continue Reading

Citations

Dec 18, 2019·Expert Review of Clinical Immunology·Alfredo J Lucendo
Dec 28, 2019·Journal of Pediatric Gastroenterology and Nutrition·Barry K Wershil, Joshua B Wechsler
Sep 19, 2019·Praxis·Rebecca Jutzi, Andreas Zeller
May 31, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alfredo J Lucendo, Piedad López-Sánchez
Mar 14, 2020·Digestive Diseases and Sciences·Daniel A SchupackJeffrey A Alexander
Oct 1, 2020·Digestive Diseases and Sciences·Ryan AlexanderKarthik Ravi
Jun 29, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S DellonUNKNOWN ORBIT2/SHP621-302 Investigators

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Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02493335
NCT03245840

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