Diagnostic application of patent blue V in sentinel lymph node biopsy for breast cancer - Is it time for a change?

Indian Journal of Cancer
Raghavan VidyaMamidipudi Thirumala Krishna

Abstract

Sentinel lymph node biopsy (SLNB) was introduced in the 1990s, as a minimally invasive procedure for staging the axilla with less morbidity to the traditional axillary lymph node dissection and is now standard management of the axilla in the early breast cancer. SLNB using the combined technique of blue dye and radioisotope is currently the recommended method for lymphatic mapping, and studies have shown high identification rates (IR) (>95%) and low false-negative rates (FNR) 5-10%. However, there are several reports raising awareness regarding patent blue V dye-induced peri-operative anaphylaxis. The main aim of this article is to highlight the emergence of patent blue dye as a new allergen and present evidence regarding the utility of alternative safer methods of evaluation of early breast cancer without compromising IR.

References

Apr 8, 2003·Annals of Surgical Oncology·Rache SimmonsMichael Osborne
Jun 17, 2008·The Journal of Allergy and Clinical Immunology·Paul Michel MertesPascal Demoly
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Paul Michel MertesUNKNOWN Groupe d'Etudes des Réactions Anaphylactoïdes Peranesthésiques
Feb 18, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Louise C SavicUNKNOWN Anaesthetic Audit and Research Matrix of Yorkshire

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