Diagnostic approach to low-renin hypertension

Clinical Endocrinology
S MonticoneP Mulatero

Abstract

Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanisms underlying the development of both essential and secondary hypertension has occurred. Approximatively 25% of the patients affected by arterial hypertension display low-renin levels, a definition that is largely arbitrary and depends on the investigated population and the specific characteristics of the assay. Most often, low-renin levels are expression of a physiological response to sodium-volume overload, but also a significant number of secondary hereditary or acquired conditions falls within this category. In a context of suppressed renin status, the concomitant examination of plasma aldosterone levels (which can be inappropriately elevated, within the normal range or suppressed) and plasma potassium are essential to formulate a differential diagnosis. To distinguish between the different forms of low-renin hypertension is of fundamental importance to address the patient to the proper clinical management, as ...Continue Reading

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Citations

Sep 22, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nuran KucukTulay Guran
Sep 19, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zehra Yavas AbaliTulay Guran
Feb 11, 2020·Blood Pressure·Jiří WidimskýRenata Cífkova
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Mar 20, 2020·Journal of the Endocrine Society·Aya SaikiMitsuhide Naruse
Sep 2, 2020·Journal of Hypertension·Massimo SalvettiMaria Lorenza Muiesan
Jan 24, 2021·Molecular and Cellular Endocrinology·Katharina R Beck, Alex Odermatt
Jan 5, 2021·Curēus·Elizabeth BengeVanessa Josef
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Mar 15, 2021·Indian Heart Journal·Saurav KhatiwadaSarah Alam
May 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Eleftheria GkaniatsaOskar Ragnarsson

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