PMID: 3319285Aug 1, 1987Paper

Diagnostic aspects of alkaline phosphatase and its isoenzymes

Clinical Biochemistry
D W Moss

Abstract

The changes in serum alkaline phosphatase that are of main diagnostic importance result from increased entry of enzyme into the circulation. This results from increased osteoblastic activity in bone disease, and increased synthesis of alkaline phosphatase by hepatocytes in hepatobiliary disease. The liver and bone forms of alkaline phosphatase are differently-glycosylated forms of a single gene product. The main value of their specific estimation is found in patients in whom bone and liver diseases co-exist, for example, as a result of cancer. Abnormal expression of genetically-distinct alkaline phosphatase isoenzymes is valuable in monitoring cancers, particularly germ-cell tumors. These isoenzymes include Regan and Nagao isoenzymes, which correspond respectively to normal placental and placental-like alkaline phosphatases, and the Kasahara isoenzyme which appears to result from re-expression of a fetal intestinal alkaline phosphatase gene.

References

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Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R A MulivorH Harris
Oct 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·K B WhitakerD W Moss
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Aug 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·A J KryszewskiD W Moss
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Citations

Dec 25, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Michael RosemannJochen Graw
Dec 9, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·L J MeyerH Harris
Dec 1, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·V KalimanovskaD W Moss
Apr 20, 2010·Research in Veterinary Science·F A Al-Sobayil
Jul 19, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoto KamiyaTomohiko Ichikawa
Aug 1, 1990·Analytical Biochemistry·J Alam, J L Cook
Jul 15, 2015·Clinical Pediatrics·Andrew S Chu, Jill G Rothschild
Jan 15, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Jean-Claude LaprazPatrice Pauly
Nov 19, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J IqbalZ H Beg
Jan 1, 1991·Journal of Clinical Laboratory Analysis·I LeibovitchB Goldwasser
Jul 21, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alejandro F Siller, Michael P Whyte
Jan 12, 2000·Journal of Orthopaedic Trauma·N M Kurdy
Oct 6, 2000·Journal of Endocrinological Investigation·S BasariaD W Ball
Nov 26, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J IqbalZ H Beg
Mar 11, 2020·Regenerative Biomaterials·Huan LianChunren Wang
Sep 15, 2020·Journal of Orthopaedics·Quirina C B S ThioJoseph H Schwab
Dec 5, 2020·Pakistan Journal of Biological Sciences : PJBS·Eman F El AzabDalia A Elgamal
Mar 13, 2014·Annals of Clinical Biochemistry·J BukowczanR Quinton
May 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·N BensaadiN Vaysse

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