Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research

Biological Psychiatry
Vasiliki MichopoulosTanja Jovanovic

Abstract

Posttraumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). Although its diagnostic features have been recently reclassified with the emergence of the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition, the disorder remains characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This heterogeneity indicates the presence of multiple neurobiological mechanisms underlying the etiology and maintenance of PTSD. Translational research spanning the past few decades has revealed several potential avenues for the identification of diagnostic biomarkers for PTSD. These include, but are not limited to, monoaminergic transmitter systems, the hypothalamic-pituitary-adrenal axis, metabolic hormonal pathways, inflammatory mechanisms, psychophysiological reactivity, and neural circuits. The current review provides an update to the literature with regard to the most promising putative PTSD biomarkers, with specific emphasis on the interaction between neurobiological influences on disease risk and symptom progression. Such biomarkers will mos...Continue Reading

References

Oct 1, 1991·Journal of Clinical Psychopharmacology·C J McDougleR L St James
Jun 1, 1991·The Journal of Nervous and Mental Disease·E B BlanchardG C McCoy
Nov 1, 1987·The American Journal of Psychiatry·B D PerryS M Southwick
Nov 1, 1987·Archives of General Psychiatry·R K PitmanJ M Claiborn
Jan 1, 1982·The Psychiatric Quarterly·E B BlanchardR J Gerardi
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Apr 1, 1993·Journal of Clinical Psychopharmacology·L M NagyD S Charney
Apr 1, 1993·Archives of General Psychiatry·S M SouthwickD S Charney
Aug 1, 1997·Archives of General Psychiatry·S M SouthwickD S Charney
Jan 14, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M MaesS Scharpé
Jan 8, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·J A Boscarino, J Chang
Feb 15, 2000·The American Journal of Psychiatry·A Y ShalevR K Pitman
Feb 13, 2001·Journal of Affective Disorders·S P Orr, W T Roth
Aug 2, 2001·The American Journal of Psychiatry·L K JacobsenT R Kosten
Aug 2, 2001·The American Journal of Psychiatry·T D GeraciotiJ W Kasckow
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Jul 3, 2002·Journal of Traumatic Stress·Edward B BlanchardConnie Veazey
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Angelika BierhausPeter P Nawroth
Mar 8, 2003·Archives of General Psychiatry·Scott P OrrUNKNOWN Harvard/Veterans Affairs Post-traumatic Stress Disorder Twin Study Investigators
Oct 31, 2003·Journal of Traumatic Stress·Nnamdi PoleCharles R Marmar
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hans Peter SöndergaardTöres Theorell
Sep 15, 2004·Neuron·Elizabeth A PhelpsJoseph E LeDoux
Oct 9, 2004·Psychoneuroendocrinology·Douglas L DelahantyMichele Walsh
Jan 29, 2005·Annals of the New York Academy of Sciences·Joseph A Boscarino
May 3, 2005·The American Journal of Psychiatry·Dewleen G BakerThomas D Geracioti

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Citations

Aug 5, 2015·Biological Psychiatry·Murray B Stein
Apr 26, 2016·Experimental Neurology·Lauren A M LeboisKerry J Ressler
May 26, 2016·Experimental Neurology·Rebecca C Hendrickson, Murray A Raskind
May 28, 2016·The Nursing Clinics of North America·Deborah Antai-Otong
Jun 2, 2016·Experimental Neurology·Vasiliki MichopoulosGretchen Neigh
Feb 22, 2017·Depression and Anxiety·Rebecca HinrichsTanja Jovanovic
Dec 19, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yue FengDing Zhi Fang
Jan 13, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Aysha WaheedHubertus Himmerich
Sep 29, 2015·Experimental Neurobiology·Hee Jin KangIn Kyoon Lyoo
Nov 9, 2018·Current Neurology and Neuroscience Reports·Rebecca C HendricksonKathleen F Pagulayan
Sep 20, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael S BreenStephen J Glatt
Jan 2, 2020·The American Journal of Psychiatry·Vasiliki MichopoulosCharles B Nemeroff
Jul 15, 2020·The Journal of Pharmacology and Experimental Therapeutics·Alexandros G Kokkosis, Stella E Tsirka
Aug 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vasiliki MichopoulosTanja Jovanovic
May 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·David F ClaytonAmi Citri
Jul 2, 2019·Database : the Journal of Biological Databases and Curation·Daniel Domingo-FernándezMagali Haas
Jun 15, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Lydia G RoosJeanette M Bennett
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Apr 23, 2020·Endocrinology, Diabetes & Metabolism·H Drew DixonCharles F Gillespie
Aug 6, 2016·Neural Plasticity·Abigail PowersCharles F Gillespie
May 8, 2018·Harvard Review of Psychiatry·Philip R SzeszkoRachel Yehuda
Jun 20, 2020·Translational Psychiatry·Amin ZandvakiliNoah S Philip
Oct 7, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ida T FonkoueJeanie Park
Dec 4, 2020·Neuroscience and Biobehavioral Reviews·Monika I Roydeva, Antje A T S Reinders
Dec 6, 2019·Pharmacology, Biochemistry, and Behavior·Rochelle N WickramasekaraDeniz Yilmazer-Hanke
Feb 9, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Antonia V SeligowskiKerry J Ressler
Dec 16, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia V SeligowskiKerry J Ressler

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