Diagnostic biomarkers of muscle injury and exertional rhabdomyolysis

Clinical Chemistry and Laboratory Medicine : CCLM
Giuseppe LippiFerruccio Ceriotti

Abstract

Early recognition of muscle injury, up to development of exertional rhabdomyolysis (ER), is essential for many clinical and practical reasons, such as planning the suitable period of recovery and deciding an appropriate time for return to exercise. Albeit magnetic resonance imaging (MRI) remains the reference technique for assessing muscle injuries, and ultrasonography (US) may be a complementary approach for easy, inexpensive and fast screening, the potential drawbacks of both techniques may be overcome by some laboratory tests, which may help guiding both diagnostic reasoning and clinical decision making. Current evidence attest that creatine kinase remains the most validated test across the clinical spectrum of muscles injuries, as its measurement may be helpful for screening subjects with suggestive signs and symptoms, its concentration substantially reflects the amount of injured muscle and its kinetics appears suitable, combined with clinics and results of imaging testing, for making decisions on return to exercise. Relatively low cost and widespread availability are additional advantages of this test. In athletes with ER, myoglobin assessment may provide adjunctive useful information, due to high predictive value for dev...Continue Reading

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Citations

Feb 19, 2020·Expert Review of Proteomics·Paul DowlingKay Ohlendieck
Jun 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Fabian Sanchis-Gomar
Jul 3, 2020·Clinical Interventions in Aging·Wolfgang KemmlerRobert Kob
Mar 29, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Emily L ChananMark E Nunnally
Mar 4, 2021·Current Sports Medicine Reports·Nathaniel S NyeFrancis G O'Connor
May 23, 2021·Scandinavian Journal of Medicine & Science in Sports·Emeric ChalchatJulien Siracusa
Sep 25, 2021·Annals of Intensive Care·Virginie TarazonaAnatole Harrois
Dec 11, 2021·Expert Review of Proteomics·Paul DowlingKay Ohlendieck

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