Diagnostic Challenge and Neuromuscular Junction Contribution to ALS Pathogenesis

Frontiers in Neurology
Maria-Letizia CampanariEdor Kabashi

Abstract

Amyotrophic lateral sclerosis (ALS) represents the major adult-onset motor neuron disease. Both human and animal studies reveal the critical implication of muscle and neuromuscular junctions (NMJs) in the initial phase of this disease. Despite the common efforts, ALS diagnosis remains particularly challenging since many other disorders can overlap yielding similar clinical phenotypic features. A combination of further research on the NMJ parameters that are specific for this disease and laboratory tests are crucial for the early determination of specific changes in the muscle, as well as in motor neuron and the prediction of ALS progression. Also, it could provide a powerful tool in the discrimination of particular ALS and ALS-mimic cases and increase the efficacy of therapeutic treatments.

References

Feb 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M J StrongW G Alvord
Jan 1, 1981·Muscle & Nerve·B W Festoff, H L Fernandez
Feb 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·R J DavenportC P Warlow
Apr 1, 1996·Neurobiology of Disease·T O Crawford, C A Pardo
Jun 1, 1997·Journal of Inherited Metabolic Disease·K H Fischbeck
Jan 14, 2000·Archives of Neurology·B J TraynorO Hardiman
Feb 19, 2000·Muscle & Nerve·M de Carvalho, M Swash
Jul 7, 2001·Journal of the Neurological Sciences·S OnoH Nakagawa
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Aug 31, 2001·Archives of Neurology·R DabbyL P Rowland
Jan 23, 2004·Experimental Neurology·Lindsey R FischerJonathan D Glass
Mar 24, 2005·Annals of Neurology·Natasa JokicVincent Meininger
Feb 24, 2006·Brain : a Journal of Neurology·Caroline VanceChristopher E Shaw
May 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andreas A ArgyriouElisabeth Chroni
Jul 27, 2007·Journal of Cellular Physiology·Matthew P Vincenti, Constance E Brinckerhoff
Mar 1, 2008·Science·Jemeen SreedharanChristopher E Shaw
Nov 6, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Mamede De Carvalho, Michael Swash
Apr 24, 2009·Current Opinion in Pharmacology·Luc Dupuis, Jean-Philippe Loeffler
Jan 1, 2008·The Open Neurology Journal·Muddasir QureshiMerit E Cudkowicz
Jun 26, 2009·Journal of the Neurological Sciences·D KeizmanV E Drory
Jul 9, 2009·Nature Reviews. Neuroscience·Arthur H M Burghes, Christine E Beattie
Aug 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Giancarlo LogroscinoUNKNOWN EURALS
Oct 3, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Niebroj-DoboszH Kwiecinski
Nov 20, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Adriano ChiòUNKNOWN Eurals Consortium
Feb 9, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiUNKNOWN European Federation of Neurological Societies
Jul 14, 2010·Journal of Neurology·I CasettaE Granieri
Nov 9, 2010·Journal of Molecular Neuroscience : MN·Michal Dadon-NachumDaniel Offen

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Methods Mentioned

BETA
transgenic
biopsy
SMA

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