Diagnostic challenges during pretreatment long-term follow-up in a patient with FIP1L1-PDGFRA-positive eosinophilia

Internal Medicine
Danijela LekovicIvo Elezovic

Abstract

Obtaining a precise characterization of eosinophilia is crucial, as successful treatment relies on the underlying etiology of the disease. Platelet-derived growth factor receptor alpha-related disorders were first specified in 2008 as a distinct group of clonal eosinophilic disorders with exceptional responsiveness to imatinib. We herein present the case of a man with myeloid neoplasm and eosinophilia in whom a definitive diagnosis could not be adequately made based on histopathological features who was ultimately diagnosed only after extensive molecular analyses and successfully treated with imatinib. In addition, we discuss the diagnostic and therapeutic approaches to treating patients presenting with eosinophilia.

References

Mar 4, 2006·International Journal of Hematology·Yasuhiro TanakaTakayuki Takahashi
Jun 20, 2006·Best Practice & Research. Clinical Haematology·A PardananiP Valent
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Peter ValentGerald J Gleich
Jan 26, 2013·American Journal of Hematology·Ayalew Tefferi
Feb 2, 2013·Archives of Pathology & Laboratory Medicine·Nathan D MontgomeryYuri D Fedoriw

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Citations

Mar 20, 2015·Internal Medicine·Naoto Takahashi

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