Diagnostic challenges in survivors of early stage lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Marleen T A van Iersel-VetSuresh Senan

Abstract

Survivors of early stage non-small cell lung cancer (NSCLC) are at risk of developing disease recurrence, as well as new lung tumors. Distinguishing metastatic disease from a second primary lung tumor (SPLC) is important, but can pose diagnostic challenges in what are often frail patients. We highlight three long-term survivors of early stage NSCLC who developed multiple new lung lesions on long-term follow-up after undergoing an initial stereotactic ablative radiotherapy procedure. New radiological lesions were always evaluated by a multidisciplinary tumor board in order to determine the optimal diagnostic procedure and treatment. When identical histological types were identified, array comparative genomic hybridization (CGH) was used to differentiate between metastases and a second primary tumor. When a tissue diagnosis is not possible, a validated calculator of tumor probability can be used to calculate the likelihood of malignancy. All patients underwent multiple episodes of curative radiotherapy. These long-term survivors of early stage NSCLC highlight the importance of radiological follow-up, and describe approaches for guiding diagnostic and therapeutic management.

References

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Aug 27, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gwendolyn H M J GriffioenSuresh Senan
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Jul 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Naomi E VerstegenSuresh Senan

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Citations

Mar 15, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alexander V LouieSuresh Senan
Nov 12, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tobias FinazziSuresh Senan

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