Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery

World Journal of Gastroenterology : WJG
Dong-Won LeeSang Woo Lee

Abstract

To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease (IBD). We retrospectively studied 165 patients with Crohn's disease (CD) and 130 patients with ulcerative colitis (UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76th to 100th percentiles of patients were diagnosed. The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before di-agnosis (OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD (OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks (OR = 6.81, 95%CI: 1.12-41.4). A diagnostic dela...Continue Reading

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Citations

Feb 5, 2019·Wiener klinische Wochenschrift·Gottfried NovacekUNKNOWN Austrian IBD Study Group (ATISG)
Jun 24, 2020·Alimentary Pharmacology & Therapeutics·Gareth J WalkerJames R Goodhand
Mar 6, 2019·World Journal of Gastroenterology : WJG·Ho Suk KangHyun Joo Jang
May 29, 2020·Clinical and Translational Gastroenterology·Corey A SiegelZhaohui Cai
Sep 27, 2020·Journal of Crohn's & Colitis·Amanda RicciutoPeter C Church
Nov 10, 2020·MMW Fortschritte der Medizin·Eva BaerRaja Atreya
Feb 6, 2021·Alimentary Pharmacology & Therapeutics·Jonathan P Segal, Philip J Smith
Jan 6, 2021·Journal of Pediatric Gastroenterology and Nutrition·Joshua GlassMichelle Tobin
May 21, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Eisuke TakeyamaTakeshi Tanigawa
Jun 30, 2021·Digestive Diseases and Sciences·Rogério Serafim ParraOmar Féres
Aug 24, 2021·Current Medical Research and Opinion·Philip O'HaganDurgesh Nandini Kahol

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Software Mentioned

R
R Foundation for
SPSS
Statistical Package for the Social Science

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