Diagnostic efficacy of contrast-enhanced breast MRI versus X-ray mammography in women with different degrees of breast density.

Acta Radiologica
Jörg BarkhausenJan Endrikat

Abstract

Detection of breast cancer in women with high breast densities is a clinical challenge. To study the influence of different degrees of breast density on the sensitivity of contrast-enhanced breast magnetic resonance imaging (CE-BMRI) versus X-ray mammography (XRM). We performed an additional analysis of two large Phase III clinical trials (G1; G2) which included women with histologically proven breast cancers, called "index cancers." Additional cancers were detected during image reading. We compared the sensitivity of CE-BMRI and XRM in women with different breast densities (ACR A→D; Version 5). For each study, six blinded readers evaluated the images. Results are given as the "Median Reader." A total of 774 patients were included, 169 had additional cancers. While sensitivity of CE-BMRI for detecting all index cancers was independent of breast density (ACR A→D) (G1: 83%→83%; G2: 91%→91%) the sensitivity of XRM declined (ACR A→D) (G1: 79%→62%; G2: 82%→64%). Thus, the sensitivity difference between both imaging modalities in ACR A breasts of 3% (G1) and 9% (G2) increased to 21% (G1) and 26% (G2) in ACR D breasts. Sensitivity of CE-BMRI for detecting at least one additional cancer increased with increasing breast density (ACR A→D...Continue Reading

References

Sep 24, 2004·AJR. American Journal of Roentgenology·Francesco SardanelliUNKNOWN Italian Trial for Breast MR in Multifocal/Multicentric Cancer
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Valerie A McCormack, Isabel dos Santos Silva
Jan 19, 2007·The New England Journal of Medicine·Norman F BoydMartin J Yaffe
Jul 10, 2007·Journal of the American College of Surgeons·UNKNOWN American College Of Radiology
Jan 15, 2008·Breast Cancer Research : BCR·Celine M VachonV Shane Pankratz
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nehmat HoussamiLes Irwig
Sep 17, 2009·Journal of Surgical Oncology·Kelli PettitJulie A Margenthaler
Feb 18, 2010·The Breast : Official Journal of the European Society of Mastology·Francesco Sardanelli
Mar 23, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Francesco SardanelliRobin Wilson
Oct 26, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Renee W Pinsky, Mark A Helvie
Jan 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N H G M PetersP H M Peeters
Nov 26, 2011·Breast Cancer Research : BCR·Norman F BoydSalomon Minkin
Apr 5, 2012·JAMA : the Journal of the American Medical Association·Wendie A BergUNKNOWN ACRIN 6666 Investigators
Sep 14, 2014·Journal of the National Cancer Institute·Brian L SpragueDiana L Miglioretti
Jan 24, 2015·AJR. American Journal of Roentgenology·Elizabeth A M O'FlynnNandita M deSouza
Nov 20, 2016·Breast Cancer Research and Treatment·Nadia RajaramSoo Hwang Teo
Dec 25, 2016·Breast Cancer Research and Treatment·Johanna O P WandersNico Karssemeijer
Dec 28, 2016·AJR. American Journal of Roentgenology·Jiyon LeeVilert A Loving
Feb 22, 2017·Radiology·Christiane K KuhlSimone Schrading
May 21, 2017·The Breast : Official Journal of the European Society of Mastology·Michelle NadlerBelinda Curpen
Jun 5, 2017·The Medical Clinics of North America·Christoph I LeeJoann G Elmore
Jun 8, 2017·Breast Cancer Research and Treatment·Nehmat HoussamiMonica Morrow
Jan 27, 2018·Journal of the American College of Radiology : JACR·Debra L MonticcioloEdward A Sickles
Jul 15, 2018·Clinical Drug Investigation·Lesley J Scott
Sep 22, 2018·The Breast : Official Journal of the European Society of Mastology·Nehmat Houssami, Christoph I Lee
Dec 24, 2018·Magnetic Resonance Imaging·Ignacio González-HuebraLuis Pina
Jan 3, 2019·European Journal of Radiology·Margarita PossoUNKNOWN BELE study group
Jan 20, 2019·Journal of Magnetic Resonance Imaging : JMRI·Ritse M MannLinda Moy
Jan 30, 2019·Journal of Magnetic Resonance Imaging : JMRI·Samantha L Heller, Linda Moy
Feb 7, 2019·Breast Cancer Research and Treatment·Ulrich BickUNKNOWN German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)
May 16, 2019·The Breast : Official Journal of the European Society of Mastology·Fredrik Strand, Sophia Zackrisson
May 28, 2019·The Breast : Official Journal of the European Society of Mastology·Marta RománUNKNOWN BELE study group
Nov 28, 2019·The New England Journal of Medicine·Marije F BakkerUNKNOWN DENSE Trial Study Group

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Software Mentioned

XRM
CE
BMRI

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